Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study.
Blood and affective markers of stress in Elite Airmen during a preparatory training course: A pilot study.
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DOI：
10.1016/j.ynstr.2021.100323
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发表时间：
2021-05
影响因子：
5
通讯作者：
Redei EE
中科院分区：
文献类型：
--
作者：
Jenz ST;Goodyear CD;TSgt Graves PR;Goldstein S;Shia MR;Redei EE
在高度紧张的环境中，具有不同压力反应的个体可以表现不同。确定应激反应的血液标志物对帮助人类在应激期间的表现具有重要意义。在应激和非应激品系大鼠的血液和脑中鉴定候选转录物，并选择重叠的显著差异表达基因。这些蛋白质的人类直系同源物的血清水平，代替血液RNA，除了经典的压力和一般的临床标志物，在33名战地飞行员进行了为期52天的预备训练课程之前，他们的课程的初始进入（COIE）。在不同的训练日，包括常规的体育锻炼或长期和激烈的身心训练，获得了五次血样和情感状态的因素，负价“威胁”和正价“挑战”。在训练过程中，氯化物（Cl），脱氢表雄酮硫酸盐（DHEA-S），肌酐激酶（CK），和总二氧化碳（TCO 2）的水平之间的飞行员谁随后毕业于他们的COIE和那些没有。血清TCO 2和神经肽Y（NPY）的时间依赖性变化，以及情感因素的挑战不同的未来毕业状态在整个培训。血清parvin beta（PARVB）水平与情感因子Threat相关，而NPY、睾酮、类辅肌动蛋白F-actin结合蛋白1（COTL 1）和C反应蛋白（CRP）水平与长期强化训练中的因子Challenge相关。这些试验数据表明，确定的血液标志物小组可以测量压力反应，这有可能推进个性化的压力管理策略。新的和经典的血清标志物的水平信号的压力在男性的严重程度。生物标志物水平反映了战场飞行员在训练中的应激反应。情感测量与长期压力后的血清生物标志物相关。
In highly stressful environments, individuals with diverging stress-reactivity can perform differently. Identification of blood markers of stress-reactivity is of major significance to help human performance during stress. Candidate transcripts were identified between stressed and non-stressed strains of rats’ blood and brain, and overlapping significant differentially expressed genes were selected. Serum levels of human orthologues of these proteins, in lieu of blood RNA, in addition to classic stress and general clinical markers, were measured in 33 Battlefield Airmen undergoing a 52 day long preparatory training course before their course of initial entry (COIE). Blood samples and factors of affective state, negative valence “Threat” and positive valence “Challenge”, were obtained five times across different days of training which included either routine physical exercise or prolonged and intense physical and mental training. During training, levels of chloride (Cl), dehydroepiandrosterone-sulfate (DHEA-S), creatinine kinase (CK), and total carbon dioxide (TCO2) differed between airmen who subsequently graduated from their COIE and those who did not. Time dependent changes of serum TCO2 and neuropeptide Y (NPY), as well as the affective factor Challenge differed by future graduation status throughout the training. Serum levels of parvin beta (PARVB) correlated with the affective factor Threat, while those of NPY, testosterone, coactosin like F-actin binding protein 1 (COTL1) and C-reactive protein (CRP) correlated with factor Challenge during the extended, intensive periods of training, consistently. These pilot data suggest that the identified panel of blood markers can measure stress responsiveness, which has the potential to advance individualized stress-management strategies. Levels of novel and classical serum markers signal stress severity in men. Biomarker levels reflect stress reactivity of Battlefield Airmen in training. Affective measures correlate with serum biomarkers after extended stress.
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DOI：
10.1177/2470547017710764
发表时间：
2017-02-01
期刊：
Chronic stress (Thousand Oaks, Calif.)
影响因子：
--
作者：
Matosin N;Cruceanu C;Binder EB
通讯作者：
Binder EB
影响因子：
3.3
作者：
Hellewell, Sarah C.;Cernak, Ibolja
通讯作者：
Cernak, Ibolja
影响因子：
10.7
作者：
Choi, J. C.;Chung, M. I.;Lee, Y. D.
通讯作者：
Lee, Y. D.
DOI：
10.35371/aoem.2019.31.e18
发表时间：
2019-08-14
影响因子：
1.3
作者：
Cho, Seunghyeon;Park, Won-Ju;Moon, Jai-Dong
通讯作者：
Moon, Jai-Dong
影响因子：
4
作者：
Hirsch, Dalay;Zukowska, Zofia
通讯作者：
Zukowska, Zofia