Sex-Specific Behavioral Response to Early Adolescent Stress in the Genetically More Stress-Reactive Wistar Kyoto More Immobile, and Its Nearly Isogenic Wistar Kyoto Less Immobile Control Strain.
Sex-Specific Behavioral Response to Early Adolescent Stress in the Genetically More Stress-Reactive Wistar Kyoto More Immobile, and Its Nearly Isogenic Wistar Kyoto Less Immobile Control Strain.
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DOI：
10.3389/fnbeh.2021.779036
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发表时间：
2021
影响因子：
3
通讯作者：
Redei EE
中科院分区：
文献类型：
--
作者：
Kim S;Gacek SA;Mocchi MM;Redei EE
遗传易感性和环境压力是已知的与压力相关的精神疾病的病因。青少年时期的环境压力被认为对成年人的情感行为特别有害。为了研究遗传压力反应差异如何改变青春期压力对成年人情感行为的影响，我们采用了两种具有不同压力反应的近交系。Wistar京都更不动（WLI）大鼠品系显示出增加的应激反应性和绝望样行为以及被动应对相比，几乎同基因的对照品系，Wistar京都更不动（WLI）。这些菌株的男性和女性暴露于上下文恐惧条件反射（CFC）在青春期早期（EA），出生后32和34天（PND）之间，并测试这种温和的EA压力在成年后的后果。早期青春期的压力显着减少焦虑样行为，在开放领域的测试（OFT）和增加社会互动和识别成年男性的两个菌株相比，控制。相反，EA应激对成年雌性的这些行为没有显著影响。与对照组相比，在EA应激后的强迫游泳试验（FST）中，遗传上应激反应性较低的WLI品系的雄性和雌性均显示出显著增加的不动性。与此相反，不动性显着衰减EA应力在成年ESTA女性相比，控制。糖皮质激素受体（Nr3c1，GR）和脑源性神经营养因子（Bdnf）的转录组学变化分别主要阐明了成年人前额叶皮层和海马中的应变和应激依赖性变化。这些结果表明，与预期相反，有限的青春期压力有利于男性通过减少焦虑和提高社会行为，并通过减少被动应对的压力更反应性的青春期女性。
Genetic predisposition and environmental stress are known etiologies of stress-related psychiatric disorders. Environmental stress during adolescence is assumed to be particularly detrimental for adult affective behaviors. To investigate how genetic stress-reactivity differences modify the effects of stress during adolescence on adult affective behaviors we employed two inbred strains with differing stress reactivity. The Wistar Kyoto More Immobile (WMI) rat strain show increased stress-reactivity and despair-like behaviors as well as passive coping compared to the nearly isogenic control strain, the Wistar Kyoto Less Immobile (WLI). Males and females of these strains were exposed to contextual fear conditioning (CFC) during early adolescence (EA), between 32 and 34 postnatal days (PND), and were tested for the consequences of this mild EA stress in adulthood. Early adolescent stress significantly decreased anxiety-like behavior, measured in the open field test (OFT) and increased social interaction and recognition in adult males of both strains compared to controls. In contrast, no significant effects of EA stress were observed in adult females in these behaviors. Both males and females of the genetically less stress-reactive WLI strain showed significantly increased immobility in the forced swim test (FST) after EA stress compared to controls. In contrast, immobility was significantly attenuated by EA stress in adult WMI females compared to controls. Transcriptomic changes of the glucocorticoid receptor (Nr3c1, GR) and the brain-derived neurotrophic factor (Bdnf) illuminate primarily strain and stress-dependent changes, respectively, in the prefrontal cortex and hippocampus of adults. These results suggest that contrary to expectations, limited adolescent stress is beneficial to males thru decreasing anxiety and enhancing social behaviors, and to the stress more-reactive WMI females by way of decreasing passive coping.
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DOI：
10.1038/npp.2009.109
发表时间：
2010-01
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
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作者：
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DOI：
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发表时间：
2012-07
期刊：
Genes, brain, and behavior
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影响因子：
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