The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography-The Maastricht Study.
The association between diabetes status, HbA1c, diabetes duration, microvascular disease, and bone quality of the distal radius and tibia as measured with high-resolution peripheral quantitative computed tomography-The Maastricht Study.
复制标题
糖尿病状况，HBA1C，糖尿病持续时间，微血管疾病以及远端半径和胫骨的骨质质量与高分辨率外周定量计算机断层扫描术测量。
DOI：
10.1007/s00198-018-4678-3
复制
发表时间：
2018-12
期刊：
影响因子：
--
通讯作者：
van den Bergh JPW
中科院分区：
文献类型：
--
作者：
de Waard EAC;de Jong JJA;Koster A;Savelberg HHCM;van Geel TA;Houben AJHM;Schram MT;Dagnelie PC;van der Kallen CJ;Sep SJS;Stehouwer CDA;Schaper NC;Berendschot TTJM;Schouten JSAG;Geusens PPMM;van den Bergh JPW
在这项针对2型糖尿病病程相对较短、主要接受良好治疗的受试者的小型横断面研究中，糖化血红蛋白和糖化血红蛋白7%(53 /摩尔)与较低的皮质密度和厚度、较高的桡骨远端皮质孔隙度、较低的胫骨远端骨小梁厚度和较高的骨小梁数量有关。研究糖尿病状态与体积骨密度(VBMD)、骨微结构以及HR-pQCT评估的桡骨远端和胫骨强度之间的关系。此外，在患有2型糖尿病(T2 DM)的参与者中，研究糖化血红蛋白(HbA1c)、糖尿病病程、微血管疾病(MVD)和骨参数之间的关系。马斯特里赫特研究的410名(桡骨)和198名(胫骨)参与者(平均年龄58岁，51%为女性)的横断面数据。糖尿病状态(正常糖代谢、糖尿病前期或T2 DM)基于口服葡萄糖耐量试验和服药史。完全调整后，糖尿病前期患者和T2 DM患者的胫骨骨小梁数量(− 4%)较低，胫骨横截面积较小(− 7%)，其余指标与vBMD、骨微结构和胫骨强度无关。在T2 DM患者中，HbA1c和Gt； 7%与较低的皮质骨密度(− 5%)、皮质厚度(− 16%)、较高的皮质孔隙率(+ 2 0%)和较高的Tb.N(+ 9%)、较高的Tb.N(+ 9%)和较低的小梁厚度(− 13%)相关。糖尿病病程和 5年与较高的Tb.N(+ 6%)有关。微血管密度的存在与任何骨参数无关。在这项研究中，糖尿病病程相对较短、主要接受良好治疗的T2 DM患者，血糖控制不足与桡骨皮质骨测量呈负相关。相反，两个部位的骨小梁数目均增加。对T2 DM患者进行更详细的骨密度和骨质量调查需要进行更大样本量的研究。本文的在线版本(10.1007/s00198-0184678-3)包含补充材料，可供授权用户使用。
In this small cross-sectional study of predominantly well-treated participants with relatively short-term type 2 diabetes duration, HbA1c > 7% (53 mmol/mol) was associated with lower cortical density and thickness and higher cortical porosity at the distal radius, lower trabecular thickness at the distal tibia, and higher trabecular number at both sites. To examine the association between diabetes status and volumetric bone mineral density (vBMD), bone microarchitecture and strength of the distal radius and tibia as assessed with HR-pQCT. Additionally—in participants with type 2 diabetes (T2DM), to examine the association between HbA1c, diabetes duration, and microvascular disease (MVD) and bone parameters. Cross-sectional data from 410 (radius) and 198 (tibia) participants of The Maastricht Study (mean age 58 year, 51% female). Diabetes status (normal glucose metabolism, prediabetes, or T2DM) was based on an oral glucose tolerance test and medication history. After full adjustment, prediabetes and T2DM were not associated with vBMD, bone microarchitecture, and strength of the radius and tibia, except for lower trabecular number (Tb.N) of the tibia (− 4%) in prediabetes and smaller cross-sectional area of the tibia (− 7%) in T2DM. In T2DM, HbA1c > 7% was associated with lower cortical vBMD (− 5%), cortical thickness (− 16%), higher cortical porosity (+ 20%) and Tb.N (+ 9%) of the radius, and higher Tb.N (+ 9%) and lower trabecular thickness (− 13%) of the tibia. Diabetes duration > 5 years was associated with higher Tb.N (+ 6%) of the radius. The presence of MVD was not associated with any bone parameters. In this study with predominantly well-treated T2DM participants with relatively short-term diabetes duration, inadequate blood glucose control was negatively associated with cortical bone measures of the radius. In contrast, trabecular number was increased at both sites. Studies of larger sample size are warranted for more detailed investigations of bone density and bone quality in patients with T2DM. The online version of this article (10.1007/s00198-018-4678-3) contains supplementary material, which is available to authorized users.
登录
查看更多内容
DOI：
10.1007/s00198-016-3614-7
发表时间：
2016-09
期刊：
Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA
影响因子：
--
作者：
Heilmeier U;Cheng K;Pasco C;Parrish R;Nirody J;Patsch JM;Zhang CA;Joseph GB;Burghardt AJ;Schwartz AV;Link TM;Kazakia G
通讯作者：
Kazakia G
DOI：
10.1056/nejmoa1114248
发表时间：
2012-07-05
期刊：
The New England journal of medicine
影响因子：
--
作者：
Inker LA;Schmid CH;Tighiouart H;Eckfeldt JH;Feldman HI;Greene T;Kusek JW;Manzi J;Van Lente F;Zhang YL;Coresh J;Levey AS;CKD-EPI Investigators
通讯作者：
CKD-EPI Investigators
影响因子：
2.8
作者：
Moayeri A;Mohamadpour M;Mousavi SF;Shirzadpour E;Mohamadpour S;Amraei M
通讯作者：
Amraei M
影响因子：
5
作者：
Cortizo, AM;Sedlinsky, C;Schurman, L
通讯作者：
Schurman, L
影响因子：
2.2
作者：
MacNeil, Joshua A.;Boyd, Steven K.
通讯作者：
Boyd, Steven K.