Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review.
Confocal Microscopy and Anterior Segment Optical Coherence Tomography Imaging of the Ocular Surface and Bleb Morphology in Medically and Surgically Treated Glaucoma Patients: A Review.
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DOI：
10.3390/ph14060581
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发表时间：
2021-06-18
期刊：
影响因子：
--
通讯作者：
Oddone F
中科院分区：
文献类型：
--
作者：
Carnevale C;Riva I;Roberti G;Michelessi M;Tanga L;Verticchio Vercellin AC;Agnifili L;Manni G;Harris A;Quaranta L;Oddone F
青光眼患者通常患有由长期施用局部抗青光眼药物引起的眼表疾病（OSD），特别是在使用防腐剂或多种药物长期治疗的情况下。此外，青光眼手术可以确定与滤过泡的形成和位置、抗有丝分裂剂的应用以及结膜内的术后伤口愈合过程相关的眼表变化。最近，多项研究评估了先进诊断成像技术（例如体内共聚焦显微镜（IVCM）和前节光学相干断层扫描（AS-OCT））在检测青光眼治疗相关OSD的微观和宏观特征中的作用。它们的临床应用仍在探索中，最近特别关注分析新药物制剂和微创手术对眼表状态的影响。在这篇综述中，我们总结了目前的知识，在IVCM和AS-OCT确定的药物治疗下，或手术治疗后的青光眼患者的眼表的主要变化。
Glaucoma patients often suffer from ocular surface disease (OSD) caused by the chronic administration of topical anti-glaucoma medications, especially in cases of long-term therapy with preserved or multiple drugs. Additionally, glaucoma surgery may determine ocular surface changes related to the formation and location of the filtering bleb, the application of anti-mitotic agents, and the post-operative wound-healing processes within the conjunctiva. Recently, several studies have evaluated the role of advanced diagnostic imaging technologies such as in vivo confocal microscopy (IVCM) and anterior segment-optical coherence tomography (AS-OCT) in detecting microscopic and macroscopic features of glaucoma therapy-related OSD. Their clinical applications are still being explored, with recent particular attention paid to analyzing the effects of new drug formulations and of minimally invasive surgical procedures on the ocular surface status. In this review, we summarize the current knowledge about the main changes of the ocular surface identified at IVCM and AS-OCT in glaucoma patients under medical therapy, or after surgical treatment.
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影响因子：
4.4
作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
2
作者：
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2
作者：
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通讯作者：
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影响因子：
4.4
作者：
Agnifili, Luca;Mastropasqua, Rodolfo;Mastropasqua, Leonardo
通讯作者：
Mastropasqua, Leonardo