Composite block polymer-microfabricated silicon nanoporous membrane.

Composite block polymer-microfabricated silicon nanoporous membrane.
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DOI:
10.1021/am900013v
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发表时间:
2009-04
影响因子:
9.5
通讯作者:
Siegel, Ronald A.
Siegel, Ronald A.
中科院分区:
材料科学2区
文献类型:
--
作者:
Nuxoll, Eric E.;Hillmyer, Marc A.;Wang, Ruifang;Leighton, C.;Siegel, Ronald A.

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嵌段聚合物提供了一个有吸引力的路线,密集包装,单分散纳米级孔。然而,它们作为薄膜的脆弱性使它们作为膜的用途复杂化。通过将嵌段聚合物膜与薄(100 μm)硅衬底集成,我们开发了一种复合膜,其提供纳米尺寸排阻和小分子的快速传输。在这里,我们描述了这种膜的制造,评估其机械完整性,并证明其传输性能的模型溶质的大小分子量。阻止大分子而不阻碍小分子的能力,加上聚合物表面改性的潜力和MEMS风格的支持,使这种复合膜成为一个有吸引力的候选人接口植入式传感和药物输送装置与生物宿主。
Block polymers offer an attractive route to densely-packed, monodisperse nanoscale pores. However, their fragility as thin films complicates their use as membranes. By integrating a block polymer film with a thin (100 μm) silicon substrate, we have developed a composite membrane providing both nanoscale size exclusion and fast transport of small molecules. Here we describe the fabrication of this membrane, evaluate its mechanical integrity, and demonstrate its transport properties for model solutes of large and small molecular weight. The ability to block large molecules without hindering smaller ones, coupled with the potential for surface modification of the polymer and the MEMS style of the support make this composite membrane an attractive candidate for interfacing implantable sensing and drug delivery devices with biological hosts.
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发表时间: 2008-09-29
影响因子: 4
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