The effect of parental allergy on childhood allergic diseases depends on the sex of the child.
The effect of parental allergy on childhood allergic diseases depends on the sex of the child.
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DOI：
10.1016/j.jaci.2012.03.042
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发表时间：
2012-08
影响因子：
14.2
通讯作者：
Ewart, Susan L.
中科院分区：
文献类型：
--
作者：
Arshad, S. Hasan;Karmaus, Wilfried;Raza, Abid;Kurukulaaratchy, Ramesh J.;Matthews, Sharon M.;Holloway, John W.;Sadeghnejad, Alireza;Zhang, Hongmei;Roberts, Graham;Ewart, Susan L.
双亲起源效应对了解儿童过敏性疾病的遗传基础和提高识别高危儿童的能力具有重要意义。目的探讨儿童过敏性疾病的父母来源效应。怀特岛出生队列（n= 1 456）在1、2、4、10和18岁时进行了检查。通过有效的问卷调查获得哮喘、湿疹、鼻炎和环境因素的患病率信息。在4岁、10岁和18岁时进行皮肤点刺试验，在10岁和18岁时进行总IgE试验。父母的过敏性疾病史进行了评估后不久出生的孩子时，母亲的IgE也进行了测量。应用对数线性模型估计患病率（PR）及其95%置信区间（CI），调整混杂变量。当按儿童性别分层时，母亲哮喘与女孩哮喘相关[PR：1.91（CI：1.34-2.72），p=0.0003]，但与男孩哮喘无关[PR：1.29（CI：0.85-1.96），p=0.23），而父亲哮喘与男孩哮喘相关[PR：1.99（CI：1.42-2.79），p<0.0001]，但与女孩哮喘无关[PR：1.03（0.59-1.80）p=0.92）。母亲湿疹仅增加女孩患湿疹的风险[PR：1.92（CI：1.37-2.68）; P=0.0001]，而父亲湿疹对男孩也有同样的作用（PR：2.07（CI：1.32-3.25）; P=0.002）。当母亲和父亲的过敏性疾病的影响进行评估儿童特应性和母亲的总IgE相关的总IgE在儿童在10岁和18岁时，观察到类似的趋势。目前的研究表明，父母的过敏性疾病与儿童过敏的性别依赖性关联;母亲过敏增加女孩和男孩的父亲过敏的风险。这对儿童过敏的预测和预防具有重要意义。
Parent of origin effect is important in understanding the genetic basis of childhood allergic diseases and to improve our ability to identify high risk children. To investigate parent of origin effect in childhood allergic diseases. The Isle of Wight Birth Cohort (n=1,456) has been examined at 1, 2, 4, 10 and 18-years. Information on prevalence of asthma, eczema, rhinitis and environmental factors was obtained using validated questionnaires. Skin prick tests were carried out at ages 4, 10 and 18 year, and total IgE at 10 and 18 years. Parental history of allergic disease was assessed soon after the birth of the child when maternal IgE was also measured. Prevalence ratios (PR) and their 95% confidence intervals (CI) were estimated, applying log-linear models, adjusted for confounding variables. When stratified for sex of the child, maternal asthma was associated with asthma in girls [PR:1.91 (CI:1.34–2.72), p=0.0003], but not in boys [PR:1.29 (CI:0.85–1.96), p=0.23), while paternal asthma was associated with asthma in boys [PR:1.99 (CI:1.42–2.79), p<0.0001], but not in girls [PR: 1.03 (0.59–1.80) p=0.92). Maternal eczema increased the risk of eczema in girls [PR: 1.92 (CI: 1.37–2.68); p=0.0001] only, while paternal eczema did the same for boys (PR: 2.07 (CI:1.32–3.25); P=0.002). Similar trends were observed when the effect of maternal and paternal allergic disease was assessed for childhood atopy and when maternal total IgE was related to total IgE in children at age 10 and 18 years. The current study indicates a sex dependent association of parental allergic conditions with childhood allergies; maternal allergy increasing the risk in girls and paternal allergy in boys. This has implications for childhood allergy prediction and prevention.
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