Bacterial flagella: twist and stick, or dodge across the kingdoms.
Bacterial flagella: twist and stick, or dodge across the kingdoms.
复制标题
DOI：
10.1371/journal.ppat.1004483
复制
发表时间：
2015-01
期刊：
影响因子：
6.7
通讯作者：
Holden NJ
中科院分区：
文献类型：
--
作者：
Rossez Y;Wolfson EB;Holmes A;Gally DL;Holden NJ
鞭毛细胞器是一种复杂的多蛋白质组合，以其细菌的旋转推进而闻名。然而，最近的研究扩大了我们对致病环境中其他功能的了解，特别是对肠道沙门氏菌、空肠弯曲杆菌、铜绿假单胞菌和大肠杆菌的粘附性和免疫调节。鞭毛介导的黏附在几种动植物病原体的宿主定植中很重要，但促进鞭毛与不同宿主组织结合的特定相互作用仍然难以捉摸。最近的工作表明，细胞器的作用就像探针一样，找到有利的表面拓扑结构来启动结合。一个新出现的主题是，更普遍的性质，如重复结合表位的离子电荷和旋转力，允许与质膜组件相互作用。与此同时，鞭毛蛋白单体是植物和动物先天免疫的重要诱导者：它们识别的差异会影响两个王国宿主感染的过程和结果。细菌进化出了不同的策略来逃避甚至促进这种特定的识别，植物病原体表现出了一些重要的差异。这些研究为细菌鞭毛在植物和动物储藏室中的功能提供了更广泛的评价。
The flagellum organelle is an intricate multiprotein assembly best known for its rotational propulsion of bacteria. However, recent studies have expanded our knowledge of other functions in pathogenic contexts, particularly adherence and immune modulation, e.g., for Salmonella enterica, Campylobacter jejuni, Pseudomonas aeruginosa, and Escherichia coli. Flagella-mediated adherence is important in host colonisation for several plant and animal pathogens, but the specific interactions that promote flagella binding to such diverse host tissues has remained elusive. Recent work has shown that the organelles act like probes that find favourable surface topologies to initiate binding. An emerging theme is that more general properties, such as ionic charge of repetitive binding epitopes and rotational force, allow interactions with plasma membrane components. At the same time, flagellin monomers are important inducers of plant and animal innate immunity: variation in their recognition impacts the course and outcome of infections in hosts from both kingdoms. Bacteria have evolved different strategies to evade or even promote this specific recognition, with some important differences shown for phytopathogens. These studies have provided a wider appreciation of the functions of bacterial flagella in the context of both plant and animal reservoirs.
登录
查看更多内容
影响因子：
6.7
作者：
Bucior I;Pielage JF;Engel JN
通讯作者：
Engel JN
影响因子：
3.1
作者：
Arora, SK;Ritchings, BW;Ramphal, R
通讯作者：
Ramphal, R
影响因子：
3.1
作者：
Arora, SK;Neely, AN;Ramphal, R
通讯作者：
Ramphal, R
DOI：
10.1073/pnas.0502040102
发表时间：
2005-06-28
影响因子：
11.1
作者：
Andersen-Nissen, E;Smith, KD;Aderem, A
通讯作者：
Aderem, A
影响因子：
30.5
作者：
Ausubel, FM
通讯作者：
Ausubel, FM