The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases.
The role of exercise-induced myokines in muscle homeostasis and the defense against chronic diseases.
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DOI：
10.1155/2010/520258
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发表时间：
2010
影响因子：
--
通讯作者：
Pedersen BK
中科院分区：
文献类型：
--
作者：
Brandt C;Pedersen BK
慢性炎症参与胰岛素抵抗、动脉粥样硬化、神经变性和肿瘤生长的发病机制。经常锻炼可以预防2型糖尿病、心血管疾病、结肠癌、乳腺癌和痴呆症。有证据表明，运动的保护作用在某种程度上可能归因于经常运动的抗炎作用。在这里，我们认为运动可以通过减少内脏脂肪量和/或在每次运动中诱导抗炎环境来发挥其抗炎作用。根据我们的理论，这种影响可能部分是通过肌肉衍生的肽介导的，即所谓的“肌因子”。收缩骨骼肌释放具有内分泌作用的肌因子，介导直接抗炎作用，和/或对内脏脂肪的特定作用。其他的肌肉因子在局部肌肉中起作用，并在脂肪氧化和葡萄糖摄取的信号通路上发挥作用。通过介导肌肉本身的抗炎作用，肌因子也可能抵消tnf驱动的胰岛素抵抗。总之，运动诱导的肌因子似乎参与介导全身和局部的抗炎作用。
Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. Regular exercise offers protection against type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, and dementia. Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise. Here we suggest that exercise may exert its anti-inflammatory effect via a reduction in visceral fat mass and/or by induction of an anti-inflammatory environment with each bout of exercise. According to our theory, such effects may in part be mediated via muscle-derived peptides, so-called “myokines”. Contracting skeletal muscles release myokines with endocrine effects, mediating direct anti-inflammatory effects, and/or specific effects on visceral fat. Other myokines work locally within the muscle and exert their effects on signalling pathways involved in fat oxidation and glucose uptake. By mediating anti-inflammatory effects in the muscle itself, myokines may also counteract TNF-driven insulin resistance. In conclusion, exercise-induced myokines appear to be involved in mediating both systemic as well as local anti-inflammatory effects.
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影响因子：
158.5
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通讯作者：
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