Signal transduction regulates schistosome reproductive biology.
Signal transduction regulates schistosome reproductive biology.
复制标题
DOI：
10.1016/j.mib.2009.06.005
复制
发表时间：
2009-08
影响因子：
5.4
通讯作者：
Oliveira, Guilherme
中科院分区：
文献类型：
--
作者：
LoVerde, Philip T.;Andrade, Luiza F.;Oliveira, Guilherme
血块寄生虫暴露了单独的性别，随着性的演变，他们在男性和女性蠕虫之间建立了复杂的关系，以至于男性和女性之间的信号在交配时启动，调节女性复制性发展和随后的卵子鸡蛋阶段负责发病机理和传播，了解女性繁殖发育的分子机制可能会确定控制传播的新目标这个主要的世界公共卫生问题的发病率表明，卵黄细胞的增殖和分化，女性特异性基因的表达和卵子胚胎发生受TGFβ途径和蛋白质酪氨酸激酶的调节。
Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent egg production. As the egg stage is responsible for pathogenesis and transmission, understanding the molecular mechanisms of female reproductive development may identify novel targets for control of transmission and morbidity of this major world public health problem. Recent data has demonstrated that the pairing process, proliferation and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFβ pathway and protein tyrosine kinases.
登录
查看更多内容
TGF-β信号传导控制寄生虫烟瘤曼森的胚胎发育。
影响因子：
6.7
作者：
Freitas TC;Jung E;Pearce EJ
通讯作者：
Pearce EJ
影响因子：
56.9
作者：
Davies, SJ;Grogan, JL;McKerrow, JH
通讯作者：
McKerrow, JH
影响因子：
4.8
作者：
Beall, MJ;Pearce, EJ
通讯作者：
Pearce, EJ
DOI：
10.1016/j.bbrc.2008.04.125
发表时间：
2008-07-11
影响因子：
3.1
作者：
Fantappie, Marcelo Rosado;Furtado, Daniel Rodrigues;LoVerde, Philip T.
通讯作者：
LoVerde, Philip T.
DOI：
10.4269/ajtmh.1985.34.508
发表时间：
1985-01-01
影响因子：
3.3
作者：
ARONSTEIN, WS;STRAND, M
通讯作者：
STRAND, M