Decreased circulating T regulatory lymphocytes in obese patients undergoing bariatric surgery.
Decreased circulating T regulatory lymphocytes in obese patients undergoing bariatric surgery.
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DOI：
10.1371/journal.pone.0197178
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Rizzoni D
中科院分区：
文献类型：
--
作者：
Agabiti-Rosei C;Trapletti V;Piantoni S;Airò P;Tincani A;De Ciuceis C;Rossini C;Mittempergher F;Titi A;Portolani N;Caletti S;Coschignano MA;Porteri E;Tiberio GAM;Pileri P;Solaini L;Kumar R;Ministrini S;Agabiti Rosei E;Rizzoni D
以前已经证明，T淋巴细胞可能参与高血压和微血管重塑的发展，并且循环T效应淋巴细胞可能在高血压中增加。特别是，Th1和Th17淋巴细胞可能有助于高血压和微血管损伤的进展，而调节性T细胞（Treg）淋巴细胞似乎在这方面具有保护作用。然而，没有关于严重肥胖患者的数据，其中观察到明显的微血管改变。我们调查了32名接受减肥手术的严重肥胖患者，以及24名血压正常的瘦型患者和12名接受择期手术干预的高血压瘦型患者。术前采集外周血样本，用于评估CD4+ T淋巴细胞亚群。通过流式细胞术评价淋巴细胞表型，以评估T效应细胞和Treg淋巴细胞。与对照组相比，在肥胖患者中观察到几种Treg亚群的显著减少，以及CD4+效应记忆T效应细胞的增加。在严重肥胖患者中，Treg淋巴细胞明显减少，CD4+效应记忆细胞增加。可以假设，它们可能有助于先前在这些患者中观察到的显著微血管改变的发展。
It has been previously demonstrated that T lymphocytes may be involved in the development of hypertension and microvascular remodeling, and that circulating T effector lymphocytes may be increased in hypertension. In particular, Th1 and Th 17 lymphocytes may contribute to the progression of hypertension and microvascular damage while T-regulatory (Treg) lymphocytes seem to be protective in this regard. However, no data is available about patients with severe obesity, in which pronounced microvascular alterations were observed. We have investigated 32 severely obese patients undergoing bariatric surgery, as well as 24 normotensive lean subjects and 12 hypertensive lean subjects undergoing an elective surgical intervention. A peripheral blood sample was obtained before surgery for assessment of CD4+ T lymphocyte subpopulations. Lymphocyte phenotype was evaluated by flow cytometry in order to assess T-effector and Treg lymphocytes. A marked reduction of several Treg subpopulations was observed in obese patients compared with controls, together with an increased in CD4+ effector memory T-effector cells. In severely obese patients, Treg lymphocytes are clearly reduced and CD4+ effector memory cells are increased. It may be hypothesized that they might contribute to the development of marked microvascular alterations previously observed in these patients.
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影响因子：
10.8
作者：
Guzik TJ;Skiba DS;Touyz RM;Harrison DG
通讯作者：
Harrison DG
适应性免疫系统在高血压中的作用。
影响因子：
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作者：
Harrison, David G.;Vinh, Antony;Lob, Heinrich;Madhur, Meena S.
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影响因子：
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影响因子：
2.4
作者：
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通讯作者：
Frisbee, Jefferson C.
影响因子：
3.2
作者：
De Ciuceis, Carolina;Rossini, Claudia;Rizzoni, Damiano
通讯作者：
Rizzoni, Damiano