Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship.
Ethnic and sex differences in bone marrow adipose tissue and bone mineral density relationship.
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DOI：
10.1007/s00198-011-1873-x
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发表时间：
2012-09
影响因子：
4
通讯作者：
Shapses, S.
中科院分区：
文献类型：
--
作者：
Shen, W.;Chen, J.;Gantz, M.;Punyanitya, M.;Heymsfield, S. B.;Gallagher, D.;Albu, J.;Engelson, E.;Kotler, D.;Pi-Sunyer, X.;Shapses, S.
关键词：
骨髓脂肪组织和骨密度之间的关系在非洲裔美国人和高加索人以及男性和女性之间是不同的。这表明调节骨髓基质细胞分化和增殖的机制在这些群体中可能不同。长期以来，人们一直认为骨矿物质密度（BMD）和骨折风险存在种族和性别差异。最近的研究表明，骨髓脂肪组织（BMAT）可能在骨质疏松症的发病机制中发挥作用。尚不清楚BMAT与BMD之间的关系是否存在种族和性别差异。使用全身T1加权磁共振成像评价了455名健康的非洲裔美国人和高加索男性和女性（年龄18-88岁）的盆腔BMAT。采用全身双能X线骨密度仪测量BMD。骨盆BMAT与全身骨密度或骨盆骨密度呈负相关（r分别=-0.533、-0.576; P<0.001）。在以BMD为因变量的多元回归分析中，种族作为个体项或与BMAT的相互作用显著进入回归模型。月经状况显著进入以全身BMD为因变量的回归模型。在相同的BMAT水平下，非裔美国人的全身BMD高于白人，BMAT较高的参与者骨盆BMD的种族差异更大。男性和绝经前妇女有较高的全身BMD水平比绝经后妇女相同量的BMAT。在非裔美国人和白人男性和女性中，BMAT和BMD之间存在反比关系。本研究中观察到的BMAT和BMD之间的种族和性别差异表明，调节骨髓基质细胞分化和增殖的机制可能在这些人群中不同。
The relationship between bone marrow adipose tissue and bone mineral density is different between African Americans and Caucasians as well as between men and women. This suggests that the mechanisms that regulate the differentiation and proliferation of bone marrow stromal cells may differ in these populations. It has long been established that there are ethnic and sex differences in bone mineral density (BMD) and fracture risk. Recent studies suggest that bone marrow adipose tissue (BMAT) may play a role in the pathogenesis of osteoporosis. It is unknown whether ethnic and sex differences exist in the relationship between BMAT and BMD. Pelvic BMAT was evaluated in 455 healthy African American and Caucasian men and women (age 18–88 years) using whole-body T1-weighted magnetic resonance imaging. BMD was measured using whole-body dual-energy X-ray absorptiometry. A negative correlation was observed between pelvic BMAT and total body BMD or pelvic BMD (r=−0.533, −0.576, respectively; P<0.001). In multiple regression analyses with BMD as the dependent variable, ethnicity significantly entered the regression models as either an individual term or an interaction with BMAT. Menopausal status significantly entered the regression model with total body BMD as the dependent variable. African Americans had higher total body BMD than Caucasians for the same amount of BMAT, and the ethnic difference for pelvic BMD was greater in those participants with a higher BMAT. Men and premeno-pausal women had higher total body BMD levels than postmenopausal women for the same amount of BMAT. An inverse relationship exists between BMAT and BMD in African American and Caucasian men and women. The observed ethnic and sex differences between BMAT and BMD in the present study suggest the possibility that the mechanisms regulating the differentiation and proliferation of bone marrow stromal cells may differ in these populations.
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DOI：
10.1097/qai.0b013e31814b94e2
发表时间：
2007-11-01
影响因子：
3.6
作者：
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DOI：
10.1038/oby.2010.106
发表时间：
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期刊：
Obesity (Silver Spring, Md.)
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影响因子：
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