MODOMICS: a database of RNA modification pathways.
MODOMICS: a database of RNA modification pathways.
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DOI：
10.1093/nar/gkj084
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发表时间：
2006-01-01
影响因子：
14.9
通讯作者：
Bujnicki, Janusz M.
中科院分区：
文献类型：
--
作者：
Dunin-Horkawicz, Stanislaw;Czerwoniec, Anna;Gajda, Michal J.;Feder, Marcin;Grosjean, Henri;Bujnicki, Janusz M.
MODOMICS是第一个针对RNA修饰的系统生物学的综合性数据库资源。它整合了有关修饰核苷的化学结构、它们在RNA序列中的定位、它们的生物合成途径以及执行各自反应的酶的信息。MODOMICS还提供文献信息以及到其他数据库的链接，包括可用的蛋白质序列和结构数据。目前的修饰和途径列表是全面的，而酶的数据集仅限于大肠杆菌和酿酒酵母，序列比对仅针对这些生物的tRNA。来自其他生物的RNA和酶将在不久的将来被包括在内。MODOMICS可以通过核苷的类型(例如，A、G、C、U、I、M1a、nm5s2U等)、RNA的类型、特定核苷的位置、反应类型(例如甲基化、硫代、脱氨等)来查询。以及感兴趣的酶的名称或序列。数据呈现的选择包括涉及查询核苷的路径图、RNA序列的多序列比对以及酶和文献数据的表格形式。MODOMICS的内容可通过万维网访问。
MODOMICS is the first comprehensive database resource for systems biology of RNA modification. It integrates information about the chemical structure of modified nucleosides, their localization in RNA sequences, pathways of their biosynthesis and enzymes that carry out the respective reactions. MODOMICS also provides literature information, and links to other databases, including the available protein sequence and structure data. The current list of modifications and pathways is comprehensive, while the dataset of enzymes is limited to Escherichia coli and Saccharomyces cerevisiae and sequence alignments are presented only for tRNAs from these organisms. RNAs and enzymes from other organisms will be included in the near future. MODOMICS can be queried by the type of nucleoside (e.g. A, G, C, U, I, m1A, nm5s2U, etc.), type of RNA, position of a particular nucleoside, type of reaction (e.g. methylation, thiolation, deamination, etc.) and name or sequence of an enzyme of interest. Options for data presentation include graphs of pathways involving the query nucleoside, multiple sequence alignments of RNA sequences and tabular forms with enzyme and literature data. The contents of MODOMICS can be accessed through the World Wide Web at .
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影响因子：
14.9
作者：
GROSJEAN, H;CONSTANTINESCO, F;BENACHENHOU, N
通讯作者：
BENACHENHOU, N
影响因子：
14.9
作者：
McCloskey JA;Rozenski J
通讯作者：
Rozenski J
影响因子：
14.9
作者：
Christie, KR;Weng, S;Cherry, JM
通讯作者：
Cherry, JM
影响因子：
4.5
作者：
Jackman, JE;Montange, RK;Phizicky, EM
通讯作者：
Phizicky, EM
DOI：
10.1007/bf00330046
发表时间：
1982-01-01
期刊：
MOLECULAR AND GENERAL GENETICS
影响因子：
--
作者：
BYSTROM, AS;BJORK, GR
通讯作者：
BJORK, GR