Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.
Combining a β3 adrenergic receptor agonist with alpha-lipoic acid reduces inflammation in male mice with diet-induced obesity.
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DOI：
10.1002/oby.23309
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Cypess AM
中科院分区：
文献类型：
--
作者：
Abdul Sater Z;Cero C;Pierce AE;Lea HJ;Abdul Sater H;Zhu KY;Liu N;Ma Y;Gavrilova O;Cypess AM
β3-肾上腺素能受体（β3-AR）刺激白色和棕色脂肪组织的脂解和产热。肥胖会增加氧化应激和炎症，从而减弱脂肪组织（AT）β3-AR信号传导。检验β3-AR激动剂CL-316，243（CL）和抗氧化剂α-硫辛酸（ALA）联合使用可降低饮食诱导肥胖（DIO）中的炎症并改善β3-AR功能的假设。将总共40只DIO小鼠分成四组：对照组（口服[PO]和腹膜内[IP]媒介物）;单独CL组（每日0.01 mg/kg IP）;单独ALA组（250 mg/kg饮用水）;或ALA+CL组合组，均持续5周。所有组的食物摄入量相似，但接受ALA+CL的小鼠表现出改善的身体组成和炎症：体重降低[对照组+1.7g vs. ALA+CL −2.5g（−7%）; P<0.01]和体脂%（− 9%，P < 0.001）。ALA+CL组的全身和附睾WAT（epiWAT）炎症低于所有其他组，epiWAT抗炎CD 206 + M2-巨噬细胞的募集增强。联合治疗组WAT中的β3-AR信号增强，产热解偶联蛋白1（UCP 1）和AT脂肪酶的mRNA和蛋白水平较高。用ALA和β3-AR激动剂长期治疗可减少DIO诱导的炎症。AT免疫调节可能是肥胖患者的治疗靶点。
β3-adrenoceptors (β3-AR) stimulate lipolysis and thermogenesis in white and brown adipose tissue. Obesity increases oxidative stress and inflammation that attenuate adipose tissue (AT) β3-AR signaling. To test the hypothesis that the combination of the β3-AR agonist CL-316,243 (CL) and the antioxidant alpha-lipoic acid (ALA) would lower inflammation in diet-induced obesity (DIO) and improve β3-AR function. A total of 40 DIO mice were separated into four groups: Control (per os [PO] and intraperitoneal [IP] vehicle); CL alone (0.01 mg/kg IP daily); ALA alone (250 mg/kg in drinking water); or ALA+CL combination, all for 5 weeks. Food intake was similar in all groups, yet mice receiving ALA+CL showed improved body composition and inflammation: lower body weight [+1.7g Control vs. −2.5g ALA+CL (−7%); P<0.01] and % body fat (−9%, P < 0.001). Systemic and epididymal WAT (epiWAT) inflammation was lower with ALA+CL than all other groups, with enhanced recruitment of epiWAT anti-inflammatory CD206+ M2-macrophages. β3-AR signaling in WAT was enhanced in the combination-treatment group, with higher mRNA and protein levels of thermogenic uncoupling protein 1 (UCP1) and AT lipases. Chronic treatment with ALA and a β3-AR agonist reduces DIO-induced inflammation. AT immune modulation could be a therapeutic target in patients with obesity.
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影响因子：
4.9
作者：
Ravussin, Y.;Gutman, R.;LeDuc, C. A.;Leibel, R. L.
通讯作者：
Leibel, R. L.
影响因子：
4.1
作者：
Park, Sungmi;Karunakaran, Udayakumar;Lee, In-Kyu
通讯作者：
Lee, In-Kyu
DOI：
10.1016/j.bbalip.2010.04.012
发表时间：
2010-09
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Mottillo EP;Shen XJ;Granneman JG
通讯作者：
Granneman JG
影响因子：
7.7
作者：
Mowers J;Uhm M;Reilly SM;Simon J;Leto D;Chiang SH;Chang L;Saltiel AR
通讯作者：
Saltiel AR
影响因子：
5.6
作者：
Kim, Seung-Jin;Choi, Youngshim;Park, Taesun
通讯作者：
Park, Taesun