Estimating energy expenditure in mice using an energy balance technique.
Estimating energy expenditure in mice using an energy balance technique.
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DOI:
10.1038/ijo.2012.105
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发表时间:
2013-03
影响因子:
4.9
通讯作者:
Leibel, R. L.
中科院分区:
文献类型:
--
作者:
Ravussin, Y.;Gutman, R.;LeDuc, C. A.;Leibel, R. L.
To compare, in mice, the accuracy of estimates of energy expenditure using an energy balance technique (TEEbal : food energy intake and body composition change) versus indirect calorimetry (TEEIC). In 32 male C57BL/6J mice energy expenditure was estimated using an energy balance (caloric intake minus change in body energy stores) method over a 37 day period. Energy expenditure was also measured in the same animals by indirect calorimetry. These measures were compared. The two methods were highly correlated (r2 = 0.87: TEEbal = 1.07 * TEEIC − 0.22, p < 0.0001). By Bland-Altman analysis, TEEbal estimates were slightly higher (4.6±1.5%; p < 0.05) than TEEIC estimates (Bias = 0.55 kcal/24h). TEEbal can be performed in “home cages” and provides an accurate integrated long-term measurement of energy expenditure while minimizing potentially confounding stress that may accompany the use of indirect calorimetry systems. The technique can also be used to assess long term energy intake.
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影响因子:
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FORSUM, E;HILLMAN, PE;NESHEIM, MC
通讯作者:
NESHEIM, MC
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Guo, Juen;Hall, Kevin D.
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通讯作者:
SCHOELLER, DA