Effects of setting on the subjective and behavioral effects of d-amphetamine in humans.

Effects of setting on the subjective and behavioral effects of d-amphetamine in humans.
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环境对 d-苯丙胺对人类主观和行为影响的影响。

DOI:
10.1016/0306-4603(92)90050-6
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发表时间:
1992
影响因子:
4.4
通讯作者:
deWit,H
deWit,H
中科院分区:
医学2区
文献类型:
--
作者:
Zacny,JP;Bodker,BK;deWit,H

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在8名健康志愿者中研究了环境对20 mg口服苯丙胺的主观和行为效应的影响。采用受试者内设计,受试者在住院(隔离实验室)或门诊(正常日常环境)环境中摄入安非他明或安慰剂胶囊。四种实验条件的顺序在受试者之间随机分配。使用情绪状态,成瘾研究中心量表,视觉焦虑量表和药物效应/喜欢问卷,在胶囊摄入前和1,3和6小时后完成,主观药物效应进行了评估。此外,在6小时时间点完成了测量总体药物喜好和药物识别的疗程结束问卷。受试者戴着手腕监测器,记录他们的身体活动水平在6小时postinguishment期间。安非他明产生典型的兴奋剂样主观效应,如兴奋、欣快和友好,但环境既不从数量上也不从质量上改变药物反应。
The effects of setting on the subjective and behavioral effects of 20 mg orald-amphetamine were studied in eight healthy volunteers. A within-subjects design was used in which subjects ingested either amphetamine or placebo capsules in either an inpatient (isolated laboratory room) or an outpatient (normal daily environment) setting. The order of the four experimental conditions was randomized across subjects. Subjective drug effects were assessed using the Profile of Mood States, the Addiction Research Center Inventory, a Visual Analogue Scale, and a Drug Effects/Liking questionnaire, completed prior to and 1, 3, and 6 h after capsule ingestion. In addition, an End-of-Session questionnaire measuring overall drug liking and drug identification was completed at the 6-h timepoint. Subjects wore wrist monitors to record their physical activity levels during the 6-h postingestion period. Amphetamine produced typical stimulant-like subjective effects such as elation, euphoria, and friendliness, but the setting neither quantitatively nor qualitatively altered the drug response.
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