Expression and Distribution of Neuropeptide-Expressing Cells Throughout the Rodent Paraventricular Nucleus of the Thalamus.
Expression and Distribution of Neuropeptide-Expressing Cells Throughout the Rodent Paraventricular Nucleus of the Thalamus.
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DOI：
10.3389/fnbeh.2020.634163
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发表时间：
2020
影响因子：
3
通讯作者：
Barson JR
中科院分区：
文献类型：
--
作者：
Curtis GR;Oakes K;Barson JR
丘脑室旁核（PVT）已被证明对情感和动机行为做出重大贡献，但对该大脑区域细胞表达的神经化学物质的全面描述从未出现过。虽然PVT被认为是由主要使用兴奋性氨基酸谷氨酸作为神经递质的投射神经元组成，但也有几种神经肽在该脑区被描述。在这篇综述文章中，我们结合已发表的文献和我们在Allen脑图谱上的观察，详细描述了整个小鼠和大鼠PVT细胞中神经肽的表达和分布，特别关注已知参与行为的神经肽。这项调查产生了几个主题。首先，虽然大多数神经肽在PVT的前后轴上表达，但它们通常呈梯度存在，其中表达最密集，但不局限于PVT的前部或后部，尽管其他神经肽在PVT的前部和后部显示出更均匀的表达，但在PVT的中部表达减少。第二，我们总体上发现，与觉醒有关的神经肽在PVT的前部表达更高。与抑郁样行为相关的神经肽在后PVT高表达，与奖励相关的神经肽在内PVT高表达，而与摄入食物和滥用药物相关的神经肽则分布在整个PVT。第三，小鼠和大鼠的神经肽表达模式和含量似乎并不相同，许多在小鼠PVT中发现的神经肽尚未在大鼠中得到证实。因此，尽管需要更多的工作来揭示单个神经肽在PVT中的表达模式和特定作用，但迄今为止的证据支持该核中存在多样化但高度组织化的神经肽系统。部分取决于它们在PVT中的位置及其投射网络，神经肽在该系统中的功能可能涉及复杂的协调，以影响情感和动机行为。
The paraventricular nucleus of the thalamus (PVT) has been shown to make significant contributions to affective and motivated behavior, but a comprehensive description of the neurochemicals expressed in the cells of this brain region has never been presented. While the PVT is believed to be composed of projection neurons that primarily use as their neurotransmitter the excitatory amino acid, glutamate, several neuropeptides have also been described in this brain region. In this review article, we combine published literature with our observations from the Allen Brain Atlas to describe in detail the expression and distribution of neuropeptides in cells throughout the mouse and rat PVT, with a special focus on neuropeptides known to be involved in behavior. Several themes emerge from this investigation. First, while the majority of neuropeptides are expressed across the antero-posterior axis of the PVT, they generally exist in a gradient, in which expression is most dense but not exclusive in either the anterior or posterior PVT, although other neuropeptides display somewhat more equal expression in the anterior and posterior PVT but have reduced expression in the middle PVT. Second, we find overall that neuropeptides involved in arousal are more highly expressed in the anterior PVT, those involved in depression-like behavior are more highly expressed in the posterior PVT, and those involved in reward are more highly expressed in the medial PVT, while those involved in the intake of food and drugs of abuse are distributed throughout the PVT. Third, the pattern and content of neuropeptide expression in mice and rats appear not to be identical, and many neuropeptides found in the mouse PVT have not yet been demonstrated in the rat. Thus, while significantly more work is required to uncover the expression patterns and specific roles of individual neuropeptides in the PVT, the evidence thus far supports the existence of a diverse yet highly organized system of neuropeptides in this nucleus. Determined in part by their location within the PVT and their network of projections, the function of the neuropeptides in this system likely involves intricate coordination to influence both affective and motivated behavior.
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DOI：
10.1016/0169-328x(88)90024-1
发表时间：
1988-11-01
期刊：
MOLECULAR BRAIN RESEARCH
影响因子：
--
作者：
BURGUNDER, JM;YOUNG, WS
通讯作者：
YOUNG, WS
影响因子：
3.8
作者：
CICCOCIOPPO, R;PANOCKA, I;MASSI, M
通讯作者：
MASSI, M
影响因子：
3
作者：
Barson JR;Mack NR;Gao WJ
通讯作者：
Gao WJ
影响因子：
3.3
作者：
Chen, Y. -W.;Rada, P. V.;Hoebel, B. G.
通讯作者：
Hoebel, B. G.
影响因子：
3.1
作者：
Choudhary, Amit G.;Somalwar, Amita R.;Kokare, Dadasaheb M.
通讯作者：
Kokare, Dadasaheb M.