The Paraventricular Nucleus of the Thalamus Is an Important Node in the Emotional Processing Network.
The Paraventricular Nucleus of the Thalamus Is an Important Node in the Emotional Processing Network.
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DOI：
10.3389/fnbeh.2020.598469
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发表时间：
2020
影响因子：
3
通讯作者：
Gao WJ
中科院分区：
文献类型：
--
作者：
Barson JR;Mack NR;Gao WJ
几十年来，丘脑室旁核（PVT）一直被认为是边缘系统的重要节点，但情绪处理的研究通常未能将其纳入其研究框架。在这里，我们建议将 PVT 视为情感处理网络的一个组成部分。通过其独特的子区域、细胞群以及与其他边缘核的联系，PVT 参与情绪的两个主要特征：唤醒和效价。 PVT，特别是前 PVT，可以通过其神经元活动促进唤醒，既作为睡眠-觉醒周期的一部分，又作为对新刺激的反应。它还参与奖赏，既对奖赏刺激做出反应，又可能通过分布在其各个次区域的特定细胞群影响反映奖赏的行为。同样，PVT 中的神经元活动通过尚未定义的子区域导致抑郁样行为。后部 PVT 尤其表现出在焦虑样行为中的作用，通常会促进但也会抑制这种行为。该分区对压力源也特别敏感，它的作用是抑制慢性压力暴露后的压力反应。除了参与无条件或初级情绪反应外，PVT 还对条件性情绪行为做出重大贡献。可以在整个 PVT 中检测到响应奖励预测线索的神经元活动，并且后部 PVT 中的内源性活动强烈预测接近或寻找行为。类似地，条件性恐惧检索期间的神经元活动在后部 PVT 中被检测到，并且其激活促进了条件性恐惧的表达。 PVT 在唤醒和效价方面的大部分参与已被证明是通过相同的一般传入和传出发生的，包括与下丘脑、前边缘和下边缘皮质、伏核和杏仁核的连接，尽管控制情绪反应的 PVT 回路的详细功能图仍有待描绘。因此，虽然存在警告并且需要做更多的工作，但 PVT 通过其与边缘系统中其他重要核团的广泛联系，似乎是情绪处理网络的一个组成部分。
The paraventricular nucleus of the thalamus (PVT) has for decades been acknowledged to be an important node in the limbic system, but studies of emotional processing generally fail to incorporate it into their investigational framework. Here, we propose that the PVT should be considered as an integral part of the emotional processing network. Through its distinct subregions, cell populations, and connections with other limbic nuclei, the PVT participates in both major features of emotion: arousal and valence. The PVT, particularly the anterior PVT, can through its neuronal activity promote arousal, both as part of the sleep-wake cycle and in response to novel stimuli. It is also involved in reward, being both responsive to rewarding stimuli and itself affecting behavior reflecting reward, likely via specific populations of cells distributed throughout its subregions. Similarly, neuronal activity in the PVT contributes to depression-like behavior, through yet undefined subregions. The posterior PVT in particular demonstrates a role in anxiety-like behavior, generally promoting but also inhibiting this behavior. This subregion is also especially responsive to stressors, and it functions to suppress the stress response following chronic stress exposure. In addition to participating in unconditioned or primary emotional responses, the PVT also makes major contributions to conditioned emotional behavior. Neuronal activity in response to a reward-predictive cue can be detected throughout the PVT, and endogenous activity in the posterior PVT strongly predicts approach or seeking behavior. Similarly, neuronal activity during conditioned fear retrieval is detected in the posterior PVT and its activation facilitates the expression of conditioned fear. Much of this involvement of the PVT in arousal and valence has been shown to occur through the same general afferents and efferents, including connections with the hypothalamus, prelimbic and infralimbic cortices, nucleus accumbens, and amygdala, although a detailed functional map of the PVT circuits that control emotional responses remains to be delineated. Thus, while caveats exist and more work is required, the PVT, through its extensive connections with other prominent nuclei in the limbic system, appears to be an integral part of the emotional processing network.
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影响因子：
2.5
作者：
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通讯作者：
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作者：
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