Understanding neuropsychiatric symptoms in Alzheimer's disease: challenges and advances in diagnosis and treatment.
Understanding neuropsychiatric symptoms in Alzheimer's disease: challenges and advances in diagnosis and treatment.
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DOI：
10.3389/fnins.2023.1263771
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发表时间：
2023
影响因子：
4.3
通讯作者：
Wang, Qin
中科院分区：
文献类型：
--
作者：
Pless, Andrew;Ware, Destany;Saggu, Shalini;Rehman, Hasibur;Morgan, John;Wang, Qin
阿尔茨海默病（AD）的神经精神症状（NPS）影响多达97%的AD患者，估计80%的当前AD患者经历这些症状。常见的与ad相关的NPS包括抑郁、焦虑、激动、攻击和冷漠。阿尔茨海默病中NPS的严重程度通常与疾病的进展和认知能力下降的程度有关。此外，这些症状还会导致发病率、死亡率、护理人员负担、养老院安置时间提前和医疗保健支出增加等显著增加。尽管NPS的患病率高，影响重大，但在AD中的临床研究明显缺乏。在本文中，我们探讨和分析NPS与AD相关的患病率、症状表现、诊断挑战和治疗方案。我们的文献综述显示，在临床环境中，区分和准确诊断与AD相关的NPS仍然是一项具有挑战性的任务。通常很难辨别NPS是继发于AD的病理生理变化还是共病精神疾病。此外，有效的药物干预措施，以及非药物治疗NPS在AD的可用性仍然有限。通过强调AD相关NPS诊断和治疗的进展和挑战，我们希望对AD背景下识别和治疗这些症状的复杂性提供新的见解，并有助于更深入地了解AD中NPS的多面性。
Neuropsychiatric symptoms (NPS) in Alzheimer’s disease (AD) affect up to 97% of AD patients, with an estimated 80% of current AD patients experiencing these symptoms. Common AD-associated NPS include depression, anxiety, agitation, aggression, and apathy. The severity of NPS in AD is typically linked to the disease’s progression and the extent of cognitive decline. Additionally, these symptoms are responsible for a significant increase in morbidity, mortality, caregiver burden, earlier nursing home placement, and greater healthcare expenditure. Despite their high prevalence and significant impact, there is a notable lack of clinical research on NPS in AD. In this article, we explore and analyze the prevalence, symptom manifestations, challenges in diagnosis, and treatment options of NPS associated with AD. Our literature review reveals that distinguishing and accurately diagnosing the NPS associated with AD remains a challenging task in clinical settings. It is often difficult to discern whether NPS are secondary to pathophysiological changes from AD or are comorbid psychiatric conditions. Furthermore, the availability of effective pharmaceutical interventions, as well as non-pharmacotherapies for NPS in AD, remains limited. By highlighting the advance and challenges in diagnosis and treatment of AD-associated NPS, we aspire to offer new insights into the complexity of identifying and treating these symptoms within the context of AD, and contribute to a deeper understanding of the multifaceted nature of NPS in AD.
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DOI：
10.1097/00006205-199211000-00018
发表时间：
1992-11-01
期刊：
The Nurse practitioner
影响因子：
--
作者：
Blair, D T;Dauner, A
通讯作者：
Dauner, A
DOI：
10.1590/s1980-57642010dn40300013
发表时间：
2010-07
期刊：
Dementia & neuropsychologia
影响因子：
--
作者：
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通讯作者：
do Vale FAC
影响因子：
4.8
作者：
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通讯作者：
Lamb LE
影响因子：
48
作者：
Barnes, Deborah E.;Yaffe, Kristine
通讯作者：
Yaffe, Kristine
影响因子：
7.2
作者：
Berman, Karen;Brodaty, Henry;Seeher, Katrin
通讯作者：
Seeher, Katrin