Olfactory tubercle stimulation alters odor preference behavior and recruits forebrain reward and motivational centers.
Olfactory tubercle stimulation alters odor preference behavior and recruits forebrain reward and motivational centers.
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DOI：
10.3389/fnbeh.2014.00081
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发表时间：
2014
影响因子：
3
通讯作者：
Wesson DW
中科院分区：
文献类型：
--
作者：
Fitzgerald BJ;Richardson K;Wesson DW
啮齿动物对气味表现出强烈的行为反应，包括对某些气味的强烈偏好或厌恶。气味对动物这些行为影响的神经机制尚不清楚。在这里，我们对嗅结节（OT）的作用进行了初步的概念验证研究，嗅结节是一种与大脑奖励和嗅觉结构具有已知解剖连接的结构，在调节气味引发的行为中的作用。我们将带有同侧双极电极的 c57bl/6 雄性小鼠植入 OT 中以施加电流，从而产生 OT 的总体激活。我们证实，对 OT 进行电刺激是有益的，小鼠经常按照固定比例的时间表进行自我刺激。在另一项实验中，在三室偏好测试中，向小鼠展示了狐狸尿液或花生气味。在没有 OT 刺激的情况下，观察到对花生气味室的显着偏好，而在存在 OT 刺激的情况下，这种偏好被消除。也许为这种行为调节提供了基础，我们发现 OT 刺激不仅显着增加了 OT 中的 c-Fos 阳性神经元数量，而且还增加了对动机行为至关重要的前脑结构，包括伏隔核和侧隔。目前的结果支持这样的观点，即 OT 是动机行为表现不可或缺的一部分，并且具有通过直接改变气味处理或通过对大脑奖励和动机结构的间接作用来调节气味享乐的能力。
Rodents show robust behavioral responses to odors, including strong preferences or aversions for certain odors. The neural mechanisms underlying the effects of odors on these behaviors in animals are not well understood. Here, we provide an initial proof-of-concept study into the role of the olfactory tubercle (OT), a structure with known anatomical connectivity with both brain reward and olfactory structures, in regulating odor-motivated behaviors. We implanted c57bl/6 male mice with an ipsilateral bipolar electrode into the OT to administer electric current and thereby yield gross activation of the OT. We confirmed that electrical stimulation of the OT was rewarding, with mice frequently self-administering stimulation on a fixed ratio schedule. In a separate experiment, mice were presented with either fox urine or peanut odors in a three-chamber preference test. In absence of OT stimulation, significant preference for the peanut odor chamber was observed which was abolished in the presence of OT stimulation. Perhaps providing a foundation for this modulation in behavior, we found that OT stimulation significantly increased the number of c-Fos positive neurons in not only the OT, but also in forebrain structures essential to motivated behaviors, including the nucleus accumbens and lateral septum. The present results support the notion that the OT is integral to the display of motivated behavior and possesses the capacity to modulate odor hedonics either by directly altering odor processing or perhaps by indirect actions on brain reward and motivation structures.
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影响因子：
3.3
作者：
Kang, N.;McCarthy, E. A.;Cherry, J. A.;Baum, M. J.
通讯作者：
Baum, M. J.
影响因子：
3.7
作者：
Bensafi M;Iannilli E;Poncelet J;Seo HS;Gerber J;Rouby C;Hummel T
通讯作者：
Hummel T
影响因子：
2.5
作者：
Illig, KR
通讯作者：
Illig, KR
影响因子：
2.5
作者：
FALLON, JH;RILEY, JN;MOORE, RY
通讯作者：
MOORE, RY