Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy.
Beyond the Barriers of Light Penetration: Strategies, Perspectives and Possibilities for Photodynamic Therapy.
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DOI：
10.7150/thno.16183
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发表时间：
2016
期刊：
影响因子：
12.4
通讯作者：
Hasan T
中科院分区：
文献类型：
--
作者：
Mallidi S;Anbil S;Bulin AL;Obaid G;Ichikawa M;Hasan T
光动力疗法（PDT）是一种基于光化学的治疗方式，其涉及通过光敏剂分子与适当波长的光照射的相互作用产生细胞毒性物质。PDT是全球范围内批准的几种癌症的治疗方式，在几种情况下，已证明在传统治疗失败的情况下有效。决定PDT疗效的关键参数是1。光敏剂（分子性质、选择性、宏观和微观定位等），2.光的应用（波长、能量密度、能量密度率、照射方式等）和3.微环境（血管分布、缺氧区域、基质组织密度、分子异质性等）。多年来，几个小组的目标是监测和操纵这些关键参数的组成部分，以提高PDT治疗的有效性。然而，PDT仍然被误解为一种表面处理，主要是由于光穿透的深度有限。在这篇综述中，我们介绍了PDT方法的最新进展，策略和前景，特别是在癌症治疗中，重点是增加光在体内无法到达的“损伤区”。这是通过一系列方法实现的，这些方法包括创新的光敏剂激发策略、增加的光毒性特异性和放大由光动力作用诱导的生物效应的生物调节方法。沿着对潜在的物理、化学和生理机制的理解日益深入，预期随着这些策略的融合，PDT的临床效用将扩展到用于癌症管理的医疗设备中的强大模式。
Photodynamic therapy (PDT) is a photochemistry based treatment modality that involves the generation of cytotoxic species through the interactions of a photosensitizer molecule with light irradiation of an appropriate wavelength. PDT is an approved therapeutic modality for several cancers globally and in several cases has proved to be effective where traditional treatments have failed. The key parameters that determine PDT efficacy are 1. the photosensitizer (nature of the molecules, selectivity, and macroscopic and microscopic localization etc.), 2. light application (wavelength, fluence, fluence rate, irradiation regimes etc.) and 3. the microenvironment (vascularity, hypoxic regions, stromal tissue density, molecular heterogeneity etc.). Over the years, several groups aimed to monitor and manipulate the components of these critical parameters to improve the effectiveness of PDT treatments. However, PDT is still misconstrued to be a surface treatment primarily due to the limited depths of light penetration. In this review, we present the recent advances, strategies and perspectives in PDT approaches, particularly in cancer treatment, that focus on increasing the 'damage zone' beyond the reach of light in the body. This is enabled by a spectrum of approaches that range from innovative photosensitizer excitation strategies, increased specificity of phototoxicity, and biomodulatory approaches that amplify the biotherapeutic effects induced by photodynamic action. Along with the increasing depth of understanding of the underlying physical, chemical and physiological mechanisms, it is anticipated that with the convergence of these strategies, the clinical utility of PDT will be expanded to a powerful modality in the armamentarium for the management of cancer.
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影响因子：
8.8
作者：
通讯作者：
--
DOI：
10.3322/caac.20114
发表时间：
2011-07
期刊：
CA: a cancer journal for clinicians
影响因子：
--
作者：
Agostinis P;Berg K;Cengel KA;Foster TH;Girotti AW;Gollnick SO;Hahn SM;Hamblin MR;Juzeniene A;Kessel D;Korbelik M;Moan J;Mroz P;Nowis D;Piette J;Wilson BC;Golab J
通讯作者：
Golab J
影响因子：
3.7
作者：
Bulin, Anne-Laure;Truillett, Charles;Dujardin, Christophe
通讯作者：
Dujardin, Christophe
影响因子：
2.3
作者：
CANTI, G;LATTUADA, D;CUBEDDU, R
通讯作者：
CUBEDDU, R
影响因子：
3.3
作者：
Bisland, SK;Lilge, L;Wilson, BC
通讯作者：
Wilson, BC