miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222.
miR-130a targets MET and induces TRAIL-sensitivity in NSCLC by downregulating miR-221 and 222.
复制标题
DOI：
10.1038/onc.2011.260
复制
发表时间：
2012-02-02
期刊：
影响因子：
8
通讯作者：
Croce, C. M.
中科院分区：
文献类型：
--
作者：
Acunzo, M.;Visone, R.;Romano, G.;Veronese, A.;Lovat, F.;Palmieri, D.;Bottoni, A.;Garofalo, M.;Gasparini, P.;Condorelli, G.;Chiariello, M.;Croce, C. M.
非小细胞肺癌（NSCLC）约占所有肺癌的80%。虽然肺癌治疗已经取得了一些进展，但患者的生存率仍然很低。已经描述了由MET原癌基因上调的两种microRNA，miR-221和miR-222，通过下调p27 kip 1、PTEN和TIMP 3，在NSCLC细胞系中增强细胞存活并诱导TRAIL抗性。在此，我们进一步研究了这一途径，并表明在肺癌细胞系中以低水平表达的miR-130 a通过靶向MET能够通过c-Jun介导的miR-221和miR-222的下调来降低NSCLC细胞中的TRAIL抗性。此外，我们发现miR-130 a降低了NSCLC的迁移能力。深入了解MET-miR-221和222轴在NSCLC耐药中的调控作用是开发NSCLC治疗新策略的关键。
Non-small cell lung cancer (NSCLC) accounts for approximately 80% of all lung cancers. While some advances in lung cancer therapy have been made, patient survival is still quite poor. Two microRNAs, miR-221 and miR-222, up-regulated by the MET proto-oncogene, have been already described to enhance cell survival and to induce TRAIL resistance in NSCLC cell lines, through the down-regulation of p27kip1, PTEN and TIMP3. Here we further investigated this pathway and showed that miR-130a, expressed at low level in lung cancer cell lines, by targeting MET was able to reduce TRAIL resistance in NSCLC cells through the c-Jun mediated downregulation of miR-221 and miR-222. Moreover, we found that miR-130a reduced NSCLC migratory capacity. A better understanding of MET-miR-221&222 axis regulation in drug resistance is the key in developing new strategies in NSCLC therapy.
登录
查看更多内容
DOI：
10.2741/2354
发表时间：
2007-05-01
期刊：
FRONTIERS IN BIOSCIENCE
影响因子：
--
作者：
Schaefer, Uta;Voloshanenko, Oksana;Walczak, Henning
通讯作者：
Walczak, Henning
影响因子：
4.7
作者：
Sorrentino, Antonio;Liu, Chang-Gong;Ferlini, Cristiano
通讯作者：
Ferlini, Cristiano
影响因子：
50.3
作者：
Garofalo M;Di Leva G;Romano G;Nuovo G;Suh SS;Ngankeu A;Taccioli C;Pichiorri F;Alder H;Secchiero P;Gasparini P;Gonelli A;Costinean S;Acunzo M;Condorelli G;Croce CM
通讯作者：
Croce CM
影响因子：
11.5
作者：
Peruzzi, Benedetta;Bottaro, Donald P.
通讯作者：
Bottaro, Donald P.
影响因子：
32.4
作者：
Wiley, SR;Schooley, K;Goodwin, RG
通讯作者：
Goodwin, RG