Increased brain age and relationships with blood-based biomarkers following concussion in younger populations.
Increased brain age and relationships with blood-based biomarkers following concussion in younger populations.
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DOI：
10.1007/s00415-023-11931-8
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发表时间：
2023-12
影响因子：
6
通讯作者：
McAllister, Thomas
中科院分区：
文献类型：
--
作者：
Mayer, Andrew R.;Meier, Timothy B.;Ling, Josef M.;Dodd, Andrew B.;Brett, Benjamin L.;Robertson-Benta, Cidney R.;Huber, Daniel L.;Van der Horn, Harm J.;Broglio, Steven P.;McCrea, Michael A.;McAllister, Thomas
脑年龄正越来越多地应用于脑损伤谱，以结合血液生物标志物来定义神经病理学变化。然而，缺乏脑震荡急性/亚急性阶段的数据，特别是在年轻人群中。预测的脑年龄差异是在大型前瞻性招募的儿童脑震荡队列和匹配的健康对照组（总N = 446）以及运动相关脑震荡的大学运动员和匹配的非接触性运动对照组（总N = 184）中独立计算的。重复性头部损伤的影响（即，暴露）在一个单独的接触性运动员队列（N = 82）中进行了检查，以及通过半结构化访谈和接触性运动参与年数量化脑震荡史。急性和亚急性脑震荡期间脑年龄增加的发现在两个队列中独立重复，相对于脑震荡运动员（6个月），儿科（4个月）的恢复证据更强。重复性头部损伤的影响存在混合证据，因为接触性运动员的脑年龄增加，但与脑震荡史或接触性运动暴露年限无关。脑震荡和接触性运动员的脑年龄没有差异。相对于非接触组，脑震荡后总tau蛋白立即（约1.5天）下降，而脑震荡和接触性运动员的促炎标志物均增加。抗炎标志物与脑年龄呈负相关，而轴突损伤标志物（神经丝光）呈正相关趋势。目前和以前的研究结果共同表明，大脑年龄差异的长期性可能是由受伤时的年龄（成人>儿童）介导的，初步研究结果表明，接触运动也可能增加大脑年龄。在线版本包含补充材料，可通过10.1007/s 00415 -023-11931-8获得。
Brain age is increasingly being applied to the spectrum of brain injury to define neuropathological changes in conjunction with blood-based biomarkers. However, data from the acute/sub-acute stages of concussion are lacking, especially among younger cohorts. Predicted brain age differences were independently calculated in large, prospectively recruited cohorts of pediatric concussion and matched healthy controls (total N = 446), as well as collegiate athletes with sport-related concussion and matched non-contact sport controls (total N = 184). Effects of repetitive head injury (i.e., exposure) were examined in a separate cohort of contact sport athletes (N = 82), as well as by quantifying concussion history through semi-structured interviews and years of contact sport participation. Findings of increased brain age during acute and sub-acute concussion were independently replicated across both cohorts, with stronger evidence of recovery for pediatric (4 months) relative to concussed athletes (6 months). Mixed evidence existed for effects of repetitive head injury, as brain age was increased in contact sport athletes, but was not associated with concussion history or years of contact sport exposure. There was no difference in brain age between concussed and contact sport athletes. Total tau decreased immediately (~ 1.5 days) post-concussion relative to the non-contact group, whereas pro-inflammatory markers were increased in both concussed and contact sport athletes. Anti-inflammatory markers were inversely related to brain age, whereas markers of axonal injury (neurofilament light) exhibited a trend positive association. Current and previous findings collectively suggest that the chronicity of brain age differences may be mediated by age at injury (adults > children), with preliminary findings suggesting that exposure to contact sports may also increase brain age. The online version contains supplementary material available at 10.1007/s00415-023-11931-8.
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影响因子：
11.2
作者：
Cole, James H.;Leech, Robert;Sharp, David J.
通讯作者：
Sharp, David J.
影响因子：
13.8
作者：
Giza CC;McCrea M;Huber D;Cameron KL;Houston MN;Jackson JC;McGinty G;Pasquina P;Broglio SP;Brooks A;DiFiori J;Duma S;Harezlak J;Goldman J;Guskiewicz K;McAllister TW;McArthur D;Meier TB;Mihalik JP;Nelson LD;Rowson S;Gill J;CARE Consortium Investigators;Foroud T;Katz B;Saykin A;Campbell DE;Svoboda S
通讯作者：
Svoboda S
影响因子：
11
作者：
Finger, Carson E.;Moreno-Gonzalez, Ines;Gutierrez, Antonia;Moruno-Manchon, Jose Felix;McCullough, Louise D.
通讯作者：
McCullough, Louise D.
影响因子：
5.7
作者：
Franke, Katja;Ziegler, Gabriel;Gaser, Christian
通讯作者：
Gaser, Christian
影响因子：
3.4
作者：
Garcia JM;Stillings SA;Leclerc JL;Phillips H;Edwards NJ;Robicsek SA;Hoh BL;Blackburn S;Doré S
通讯作者：
Doré S