Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico.
Parallel evolution of vgsc mutations at domains IS6, IIS6 and IIIS6 in pyrethroid resistant Aedes aegypti from Mexico.
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DOI：
10.1038/s41598-018-25222-0
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发表时间：
2018-04-30
影响因子：
4.6
通讯作者：
Black WC 4th
中科院分区：
文献类型：
--
作者：
Saavedra-Rodriguez K;Maloof FV;Campbell CL;Garcia-Rejon J;Lenhart A;Penilla P;Rodriguez A;Sandoval AA;Flores AE;Ponce G;Lozano S;Black WC 4th
埃及伊蚊是导致登革热、寨卡和基孔肯雅热病毒的主要城市蚊子媒介，目前仍缺乏疫苗和有效的药物。目前抑制虫媒病毒爆发的战略包括清除幼虫繁殖地和对幼虫和成虫进行杀虫剂处理。对Ae的控制。由于最近全球对拟除虫菊酯类杀虫剂的击倒抗性迅速增加，埃及伊蚊具有挑战性。广泛、大量使用的拟除虫菊酯太空喷雾剂对kdr产生了巨大的选择压力，kdr主要受电压门控钠通道基因（vgsc）控制。迄今为止，已发现并发表了11种vgsc替代物，并显示其与拟除虫菊酯抗性不同程度相关。在墨西哥，F1，534C和V1，016I在过去的16年里在Ae共同进化。埃及人。最近，在巴西发现了一种新的替代品V410L，并通过电生理学证实了其对vgsc的作用。在此，我们在25个Ae中筛选V410L。在墨西哥的埃及伊蚊历史标本中，第一个杂合子出现在2002年，在过去的16年中，频率随着V1，016I和F1，534C而增加。了解特定的vgsc替代物及其相互作用以产生耐药性，对于预测和制定耐药性管理策略至关重要。
Aedes aegypti is the primary urban mosquito vector of viruses causing dengue, Zika and chikungunya fevers –for which vaccines and effective pharmaceuticals are still lacking. Current strategies to suppress arbovirus outbreaks include removal of larval-breeding sites and insecticide treatment of larval and adult populations. Insecticidal control of Ae. aegypti is challenging, due to a recent rapid global increase in knockdown-resistance (kdr) to pyrethroid insecticides. Widespread, heavy use of pyrethroid space-sprays has created an immense selection pressure for kdr, which is primarily under the control of the voltage-gated sodium channel gene (vgsc). To date, eleven replacements in vgsc have been discovered, published and shown to be associated with pyrethroid resistance to varying degrees. In Mexico, F1,534C and V1,016I have co-evolved in the last 16 years across Ae. aegypti populations. Recently, a novel replacement V410L was identified in Brazil and its effect on vgsc was confirmed by electrophysiology. Herein, we screened V410L in 25 Ae. aegypti historical collections from Mexico, the first heterozygote appeared in 2002 and frequencies have increased in the last 16 years alongside V1,016I and F1,534C. Knowledge of the specific vgsc replacements and their interaction to confer resistance is essential to predict and to develop strategies for resistance management.
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影响因子：
3.8
作者：
Vera-Maloof FZ;Saavedra-Rodriguez K;Elizondo-Quiroga AE;Lozano-Fuentes S;Black Iv WC
通讯作者：
Black Iv WC
影响因子：
1.9
作者：
Brengues, C;Hawkes, NJ;Hemingway, J
通讯作者：
Hemingway, J
影响因子：
2.1
作者：
Ponce-Garcia, Gustavo;Del Rio-Galvan, Samantha;Flores, Adriana E.
通讯作者：
Flores, Adriana E.
DOI：
10.1590/s0074-02762005000400017
发表时间：
2005-07-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
da-Cunha, Marcella Pereira;Lima, José Bento Pereira;Valle, Denise
通讯作者：
Valle, Denise
DOI：
10.1006/bbrc.1997.7511
发表时间：
1997-10-29
影响因子：
3.1
作者：
Park, Y;Taylor, MFJ;Feyereisen, R
通讯作者：
Feyereisen, R