The role of left ventrolateral prefrontal cortex during episodic decisions: semantic elaboration or resolution of episodic interference?
The role of left ventrolateral prefrontal cortex during episodic decisions: semantic elaboration or resolution of episodic interference?
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DOI：
10.1162/jocn_a_00133
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发表时间：
2012-01
影响因子：
3.2
通讯作者：
Dobbins IG
中科院分区：
文献类型：
--
作者：
Han S;O'Connor AR;Eslick AN;Dobbins IG
Context memory retrieval tasks often implicate left ventrolateral prefrontal cortex (LVPFC) during functional imaging. Although this region has been linked to controlled semantic processing of materials, it may also play a more general role in selecting among competing episodic representations during demanding retrieval tasks. Thus the LVPFC response during context memory retrieval may reflect either semantic processing of memoranda or adjudication of interfering episodic memories evoked by memoranda. To distinguish between these hypotheses we contrasted context and item memory retrieval tasks for meaningful and non-meaningful memoranda using functional Magnetic Resonance Imaging (fMRI). Increased LVPFC activation during context compared to item memory only occurred for meaningful memory probes. In contrast, even demanding context retrieval for non-meaningful materials failed to engage LVPFC. These data demonstrate that the activation previously seen during episodic tasks likely reflects semantic processing of the probes during episodic retrieval attempt, not selection among competing elicited episodic representations. Posterior middle temporal gyrus and the body/head of the caudate demonstrated the same selective response as LVPFC, although resting state functional connectivity analyses suggested these two regions likely shared separate functional relationships with the LVPFC.
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DOI：
10.1073/pnas.0504136102
发表时间：
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影响因子：
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