Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades.
Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades.
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富含白藜芦醇的水稻会通过下调炎症性级联反应来减弱UVB-ROS诱导的皮肤老化。
DOI：
10.1155/2017/8379539
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发表时间：
2017
影响因子：
--
通讯作者：
Kim SY
中科院分区：
文献类型：
--
作者：
Subedi L;Lee TH;Wahedi HM;Baek SH;Kim SY
皮肤是人体内外环境之间最外层的保护屏障。长期暴露于紫外线（UV）辐射是皮肤老化的主要原因。UVB辐射穿透皮肤并诱导活性氧产生，从而激活三种主要的皮肤老化级联反应：基质金属蛋白酶-（MMP-）1介导的老化; MAPK-AP-1/NF-κB-TNF-α/IL-6、iNOS和考克斯-2介导的炎症诱导的老化;以及p53-γ-裂解的半胱天冬酶-3-细胞色素C介导的凋亡诱导的老化。这些机制共同负责UVB诱导的皮肤老化的光老化和光老化特性。迫切需要一种治疗方法，不仅控制这些途径以防止皮肤老化，而且避免在以集中剂量施用生物活性化合物时经常遇到的不良反应。在这项研究中，我们调查了转基因普通食用大米（NR）的功效，这种大米能产生抗衰老化合物白藜芦醇（R），作为皮肤衰老的治疗方法。这种富含白藜芦醇的大米（RR）克服了R的缺点，并通过控制上述三种主要的皮肤衰老途径来增强其抗衰老潜力。RR没有表现出单独的R的毒性，并且有望下调UVB-ROS诱导的皮肤老化的潜在途径。这些发现提倡使用RR作为抗衰老目的的营养药物。
The skin is the outermost protective barrier between the internal and external environments in humans. Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging. UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging. These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging. There is an urgent requirement for a treatment that not only controls these pathways to prevent skin aging but also avoids the adverse effects often encountered when applying bioactive compounds in concentrated doses. In this study, we investigated the efficacy of genetically modified normal edible rice (NR) that produces the antiaging compound resveratrol (R) as a treatment for skin aging. This resveratrol-enriched rice (RR) overcomes the drawbacks of R and enhances its antiaging potential by controlling the abovementioned three major pathways of skin aging. RR does not exhibit the toxicity of R alone and promisingly downregulates the pathways underlying UVB-ROS-induced skin aging. These findings advocate the use of RR as a nutraceutical for antiaging purposes.
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