Relationship between plasma fibrinogen levels and pulmonary function in the japanese population: the Takahata study.
Relationship between plasma fibrinogen levels and pulmonary function in the japanese population: the Takahata study.
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DOI：
10.7150/ijms.7256
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发表时间：
2013
影响因子：
3.6
通讯作者：
Kubota I
中科院分区：
文献类型：
--
作者：
Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato M;Sato K;Kimura T;Nemoto T;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
背景：血浆纤维蛋白原被认为是呼吸系统疾病的生物标志物，因为在西方人群中建立了血浆纤维蛋白原和肺功能之间的关系。然而，这种关系尚未在亚洲人群中得到证实。我们评估了日本普通人群中的这种关系。方法：2004年至2006年，在日本高田市参加以社区为基础的年度健康体检的3，257名年龄≥40岁的男性和女性接受肺功能测定，并测定其血浆纤维蛋白原水平。结果：我们发现男性肺功能测定（预测用力肺活量百分比[%FVC]和1秒用力呼气量[%FEV1]，以及FEV 1/FVC）与血浆纤维蛋白原水平呈负相关，但女性无此相关性。限制性、阻塞性和混合性呼吸障碍患者的血浆纤维蛋白原水平显著高于肺功能正常者。多元线性回归分析显示，在男性中，血浆纤维蛋白原水平可预测%FVC和%FEV1（与年龄、体重指数和吸烟无关），但不能预测FEV 1/FVC。结论：血浆纤维蛋白原与日本男性肺功能显着相关，因此，血浆纤维蛋白原可能是男性肺功能障碍的有效生物标志物。
Background:Plasma fibrinogen is considered a biomarker of respiratory disease, owing to the relationship between plasma fibrinogen and pulmonary function established in Western populations. However, such a relationship has not yet been confirmed in an Asian population. We assessed this relationship in the general Japanese population. Methods:Totally, 3,257 men and women aged ≥40 years who participated in a community-based annual health checkup in Takahata, Japan, from 2004 to 2006, underwent spirometry, and their plasma fibrinogen levels were determined. Results:We found an inverse relationship between spirometric measures (percent predicted forced vital capacity [%FVC] and forced expiratory volume in 1s [%FEV1], and FEV1/FVC) and plasma fibrinogen levels in men, but not in women. The plasma fibrinogen levels were significantly higher in subjects with restrictive, obstructive, and mixed ventilatory disorders than in those with normal spirometry results. Multiple linear regression analysis revealed that in men, plasma fibrinogen levels were predictive for %FVC and %FEV1 (independent of age, body mass index, and cigarette smoking) but not for FEV1/FVC. Conclusions:Plasma fibrinogen was significantly associated with pulmonary function in Japanese men, and as such, plasma fibrinogen might be a potent biomarker for pulmonary dysfunction in men.
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影响因子：
3.6
作者：
Aida Y;Shibata Y;Osaka D;Abe S;Inoue S;Fukuzaki K;Tokairin Y;Igarashi A;Yamauchi K;Nemoto T;Nunomiya K;Kishi H;Sato M;Watanabe T;Konta T;Kawata S;Kato T;Kubota I
通讯作者：
Kubota I
影响因子：
9.6
作者：
Kubo, H;Nakayama, K;Sasaki, H
通讯作者：
Sasaki, H
影响因子：
3.5
作者：
Cho, Michael H.;Castaldi, Peter J.;Silverman, Edwin K.
通讯作者：
Silverman, Edwin K.
影响因子：
3.6
作者：
Sato M;Shibata Y;Abe S;Inoue S;Igarashi A;Yamauchi K;Aida Y;Kishi H;Nunomiya K;Nakano H;Sato K;Watanabe T;Konta T;Ueno Y;Kato T;Kayama T;Kubota I
通讯作者：
Kubota I
影响因子：
30.8
作者：
Repapi, Emmanouela;Sayers, Ian;Tobin, Martin D.
通讯作者：
Tobin, Martin D.