Neural correlates of nesting behavior in zebra finches (Taeniopygia guttata).
Neural correlates of nesting behavior in zebra finches (Taeniopygia guttata).
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DOI：
10.1016/j.bbr.2014.01.043
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Healy, Susan D.
中科院分区：
文献类型：
--
作者：
Hall, Zachary. I.;Bertin, Marion;Bailey, Ida E.;Meddle, Simone L.;Healy, Susan D.
我们比较标记的神经活动筑巢行为在斑胸草雀。我们可视化立即早期基因（Fos）表达筑巢和控制雀。运动，社会和奖励神经回路中的Fos产生与筑巢相关。在雄性筑巢雀中，Fos生产与材料拾取相关。在雌性筑巢雀中，Fos的产生与在巢中花费的时间相关。鸟类筑巢涉及一个行为序列（筑巢材料的收集和在巢中的沉积），这为解决大脑如何排列运动动作提供了一个独特的模型。在这项研究中，我们确定了大脑区域参与筑巢行为的男性和女性斑胸草雀（Taeniopygia guttata）。我们使用Fos免疫组织化学来量化大脑中即刻早期基因蛋白产物Fos（神经元活动的分子指标）的产生，并将这种表达与筑巢行为的变化相关联。使用这种技术，我们发现参与运动排序，社会行为，奖励和动机的神经回路在筑巢过程中是活跃的。在成对的筑巢鸟中，雄性拾起或放置筑巢材料的次数以及雌性在巢中花费的时间解释了前运动通路、社会行为网络和奖励神经回路中Fos表达的变化。识别出参与筑巢的大脑区域，使我们能够开始研究神经水平上的运动排序、背景和奖励在构建行为中的作用。
We compare markers of neural activity to nesting behavior in zebra finches. We visualized immediate early gene (Fos) expression in nesting and control finches. Fos production in motor, social, and reward neural circuits correlated with nesting. Fos production correlated with material pick-up in male nesting finches. Fos production correlated with time spent in the nest in female nesting finches. Nest building in birds involves a behavioral sequence (nest material collection and deposition in the nest) that offers a unique model for addressing how the brain sequences motor actions. In this study, we identified brain regions involved in nesting behavior in male and female zebra finches (Taeniopygia guttata). We used Fos immunohistochemistry to quantify production of the immediate early gene protein product Fos (a molecular indicator of neuronal activity) in the brain correlated this expression with the variation in nesting behavior. Using this technique, we found that neural circuitry involved in motor sequencing, social behavior, reward and motivation were active during nesting. Within pairs of nesting birds, the number of times a male picked up or deposited nesting material and the amount of time a female spent in the nest explained the variation in Fos expression in the anterior motor pathway, social behavior network, and reward neural circuits. Identification of the brain regions that are involved in nesting enables us to begin studying the roles of motor sequencing, context, and reward in construction behavior at the neural level.
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影响因子：
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