Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey.
Selecting adequate exposure biomarkers of diisononyl and diisodecyl phthalates: data from the 2005-2006 National Health and Nutrition Examination Survey.
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DOI：
10.1289/ehp.1002316
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发表时间：
2011-01
影响因子：
10.4
通讯作者：
Needham LL
中科院分区：
文献类型：
--
作者：
Calafat AM;Wong LY;Silva MJ;Samandar E;Preau JL Jr;Jia LT;Needham LL
高分子量邻苯二甲酸酯，如邻苯二甲酸二异壬酯（DINP）和邻苯二甲酸二异癸酯（DIDP），主要用作聚氯乙烯增塑剂。我们评估了来自2005-2006年国家健康和营养检查调查（NHANES）的美国一般人群中≥ 6岁的代表性样本的DINP和DIDP暴露量。我们分析了2,548尿液样本，通过使用在线固相萃取耦合同位素稀释高效液相色谱-串联质谱。我们分别在95.2%和89.9%的样品中检测到邻苯二甲酸单羧基异辛酯（MCOP）（DINP的代谢产物）和邻苯二甲酸单羧基异壬酯（MCNP）（DIDP的代谢产物）。我们检测到邻苯二甲酸单异壬酯（MNP，DINP的次要代谢产物）的频率要低得多（12.9%），浓度范围（> 0.8 μg/L-148.1 μg/L）远低于MCOP（> 0.7 μg/L-4，961 μg/L）。校正后的MCOP和MCNP几何平均浓度在儿童中显著高于青少年和成人（p < 0.01）。美国一般人群（包括儿童）暴露于DINP和DIDP。在之前的NHANES周期中，通过使用MNP作为唯一的尿液生物标志物，人体暴露于DINP的发生率被低估，因此说明了选择最适当的生物标志物进行暴露评估的重要性。
High-molecular-weight phthalates, such as diisononyl phthalate (DINP) and diisodecyl phthalate (DIDP), are used primarily as polyvinyl chloride plasticizers. We assessed exposure to DINP and DIDP in a representative sample of persons ≥ 6 years of age in the U.S. general population from the 2005–2006 National Health and Nutrition Examination Survey (NHANES). We analyzed 2,548 urine samples by using online solid-phase extraction coupled to isotope dilution high-performance liquid chromatography–tandem mass spectrometry. We detected monocarboxyisooctyl phthalate (MCOP), a metabolite of DINP, and monocarboxyisononyl phthalate (MCNP), a metabolite of DIDP, in 95.2% and 89.9% of the samples, respectively. We detected monoisononyl phthalate (MNP), a minor metabolite of DINP, much less frequently (12.9%) and at concentration ranges (> 0.8 μg/L–148.1 μg/L) much lower than MCOP (> 0.7 μg/L– 4,961 μg/L). Adjusted geometric mean concentrations of MCOP and MCNP were significantly higher (p < 0.01) among children than among adolescents and adults. The general U.S. population, including children, was exposed to DINP and DIDP. In previous NHANES cycles, the occurrence of human exposure to DINP by using MNP as the sole urinary biomarker has been underestimated, thus illustrating the importance of selecting the most adequate biomarkers for exposure assessment.
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影响因子：
3.3
作者：
Adamsson, A.;Salonen, V.;Toppari, J.
通讯作者：
Toppari, J.
DOI：
10.1016/j.ijheh.2009.08.002
发表时间：
2009-11-01
影响因子：
6
作者：
Becker, Kerstin;Goeen, Thomas;Kolossa-Gehring, Marike
通讯作者：
Kolossa-Gehring, Marike
DOI：
10.1016/j.ijheh.2007.01.024
发表时间：
2007-05-01
影响因子：
6
作者：
Angerer, Juergen;Ewers, Ulrich;Wilhelm, Michael
通讯作者：
Wilhelm, Michael
影响因子：
--
作者：
Calafat, AM;Ye, XY;Needham, LL
通讯作者：
Needham, LL
影响因子：
3.3
作者：
Hushka, LJ;Waterman, SJ;McKee, RH
通讯作者：
McKee, RH