Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
Anthropometric measures, body mass index, and pancreatic cancer: a pooled analysis from the Pancreatic Cancer Cohort Consortium (PanScan).
复制标题
DOI：
10.1001/archinternmed.2010.63
复制
发表时间：
2010-05-10
影响因子：
--
通讯作者：
Patel, Alpa V.
中科院分区：
文献类型：
--
作者：
Arslan, Alan A.;Helzlsouer, Kathy J.;Kooperberg, Charles;Shu, Xiao-Ou;Steplowski, Emily;Bueno-de-Mesquita, H. Bas;Fuchs, Charles S.;Gross, Myron D.;Jacobs, Eric J.;LaCroix, Andrea Z.;Petersen, Gloria M.;Stolzenberg-Solomon, Rachael Z.;Zheng, Wei;Albanes, Demetrius;Amundadottir, Laufey;Bamlet, William R.;Barricarte, Aurelio;Bingham, Sheila A.;Boeing, Heiner;Boutron-Ruault, Marie-Christine;Buring, Julie E.;Chanock, Stephen J.;Clipp, Sandra;Gaziano, J. Michael;Giovannucci, Edward L.;Hankinson, Susan E.;Hartge, Patricia;Hoover, Robert N.;Hunter, David J.;Hutchinson, Amy;Jacobs, Kevin B.;Kraft, Peter;Lynch, Shannon M.;Manjer, Jonas;Manson, JoAnn E.;McTiernan, Anne;McWilliams, Robert R.;Mendelsohn, Julie B.;Michaud, Dominique S.;Palli, Domenico;Rohan, Thomas E.;Slimani, Nadia;Thomas, Gilles;Tjonneland, Anne;Tobias, Geoffrey S.;Trichopoulos, Ditnitrios;Virtamo, Jarmo;Wolpin, Brian M.;Yu, Kai;Zeleniuch-Jacquotte, Anne;Patel, Alpa V.
对 NCI 胰腺癌队列联盟 (PanScan) 的汇总数据进行分析，以研究诊断前人体测量指标与胰腺癌风险之间的关联。 PanScan 采用巢式病例对照研究设计，包括 2,170 例病例和 2,209 例对照。使用无条件逻辑回归对体重指数 (BMI)、体重、身高、腰围和腰臀比 (WHR) 的队列特定四分位数以及传统 BMI 类别：体重不足 (<18.5 kg/m2)、正常 (18.5-24.9 kg/m2)、超重估计优势比 (OR) 和 95% 置信区间 (CI) （25.0-29.9 kg/m2）、肥胖（30.0-34.9 kg/m2）、重度肥胖（≥35.0 kg/m2）。针对潜在的混杂因素对模型进行了调整。在所有受试者中，观察到 BMI 增加与胰腺癌风险之间呈正相关（调整后 BMI 最高与最低四分位数的 OR = 1.33，95% CI = 1.12-1.58，Ptrend < 0.001）。在男性中，BMI 最高与最低四分位数的胰腺癌调整 OR 为 1.33（95% CI = 1.04-1.69，Ptrend <0.03）。在女性中，BMI 最高四分位数的胰腺癌调整 OR 为 1.34（95% CI = 1.05-1.70，Ptrend = 0.01）。女性腰臀比增加与胰腺癌风险增加相关（最高与最低四分位数的调整 OR = 1.87，95% CI = 1.31-2.69，Ptrend = 0.003），但在男性中则较少。研究结果为 BMI 与胰腺癌风险之间的正相关性提供了强有力的支持。此外，集中的脂肪分布可能会增加胰腺癌的风险，尤其是女性。
Pooled data were analyzed from the NCI Pancreatic Cancer Cohort Consortium (PanScan) to study the association between pre-diagnostic anthropometric measures and risk of pancreatic cancer. PanScan applied a nested case-control study design and included 2,170 cases and 2,209 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression for cohort-specific quartiles of body mass index (BMI), weight, height, waist circumference, and waist-to-hip ratio (WHR), as well as conventional BMI categories: underweight (<18.5 kg/m2), normal (18.5-24.9 kg/m2), overweight (25.0-29.9 kg/m2), obese (30.0-34.9 kg/m2), and severely obese (≥35.0 kg/m2). Models were adjusted for potential confounders. Among all subjects, a positive association between increasing BMI and risk of pancreatic cancer was observed (adjusted OR for the highest vs. lowest BMI quartile = 1.33, 95% CI = 1.12-1.58, Ptrend < 0.001). Among men, the adjusted OR for pancreatic cancer for the highest vs. lowest quartile of BMI was 1.33 (95% CI = 1.04-1.69, Ptrend <0.03). Among women, the adjusted OR for pancreatic cancer for the highest quartile of BMI was 1.34 (95% CI = 1.05-1.70, Ptrend = 0.01). Increased WHR was associated with increased risk of pancreatic cancer among women (adjusted OR for the highest vs. lowest quartile = 1.87, 95% CI = 1.31-2.69, Ptrend = 0.003) but less so in men. The findings provide strong support for a positive association between BMI and pancreatic cancer risk. In addition, centralized fat distribution may increase pancreatic cancer risk, especially in women.
登录
查看更多内容
DOI：
10.1016/s0197-2456(00)00097-0
发表时间：
2000-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
Gohagan, JK;Prorok, PC;Kramer, BS
通讯作者：
Kramer, BS
影响因子：
8.8
作者：
通讯作者：
--
影响因子：
6.4
作者：
GHADIRIAN, P;SIMARD, A;BOYLE, P
通讯作者：
BOYLE, P
影响因子：
6.4
作者：
Kuriyama, S;Tsubono, Y;Tsuji, I
通讯作者：
Tsuji, I
影响因子：
158.5
作者：
Calle, EE;Rodriguez, C;Thun, MJ
通讯作者：
Thun, MJ