Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity.
Task-Evoked Negative BOLD Response in the Default Mode Network Does Not Alter Its Functional Connectivity.
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DOI：
10.3389/fncom.2018.00067
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发表时间：
2018
影响因子：
3.2
通讯作者：
Razlighi QR
中科院分区：
文献类型：
--
作者：
Razlighi QR
虽然功能连接网络通常是从静息状态fMRI扫描中提取的，但它们在任务执行过程中也被证明是活跃的。然而，扫描仪内任务对功能连接网络的影响还没有完全了解。虽然有证据表明，任务诱发的积极BOLD反应可以改变功能连接网络，特别是在初级感觉运动皮层，任务诱发的消极BOLD反应的默认模式网络（DMN）的功能连接的影响是有点模糊。在这项研究中，我们的目的是调查是否任务的表现，这是与负BOLD反应在DMN地区，改变了独立成分分析（伊卡）获得的相同地区的功能连接的时间过程。伊卡已被用来有效地提取功能连接网络在任务执行和休息状态。我们首先证明，执行一个简单的视觉运动任务改变了从初级视觉皮层提取的网络的时间过程。然后，我们表明，尽管检测到一个强大的任务诱发的负BOLD反应在DMN区域，一个简单的视觉运动任务不会改变DMN区域的功能连接。我们的研究结果表明，不同的机制可能是人类大规模脑网络中任务相关的激活/去激活网络和重叠的功能连接网络之间的关系。
While functional connectivity networks are often extracted from resting-state fMRI scans, they have been shown to be active during task performance as well. However, the effect of an in-scanner task on functional connectivity networks is not completely understood. While there is evidence that task-evoked positive BOLD response can alter functional connectivity networks, particularly in the primary sensorimotor cortices, the effect of task-evoked negative BOLD response on the functional connectivity of the Default mode network (DMN) is somewhat ambiguous. In this study, we aim to investigate whether task performance, which is associated with negative BOLD response in the DMN regions, alters the time-course of functional connectivity in the same regions obtained by independent component analysis (ICA). ICA has been used to effectively extract functional connectivity networks during task performance and resting-state. We first demonstrate that performing a simple visual-motor task alters the temporal time-course of the network extracted from the primary visual cortex. Then we show that despite detecting a robust task-evoked negative BOLD response in the DMN regions, a simple visual-motor task does not alter the functional connectivity of the DMN regions. Our findings suggest that different mechanisms may underlie the relationship between task-related activation/deactivation networks and the overlapping functional connectivity networks in the human large-scale brain networks.
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影响因子：
5.7
作者：
Boynton, Geoffrey M.;Engel, Stephen A.;Heeger, David J.
通讯作者：
Heeger, David J.
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
1.7
作者：
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通讯作者：
Williamson, Peter
影响因子：
4.8
作者：
Calhoun, VD;Adali, T;Pekar, JJ
通讯作者：
Pekar, JJ
影响因子：
3.2
作者：
Greicius, MD;Menon, V
通讯作者：
Menon, V