Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway.
Cadherin 6 is a new RUNX2 target in TGF-β signalling pathway.
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DOI：
10.1371/journal.pone.0075489
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Ciarrocchi A
中科院分区：
文献类型：
--
作者：
Sancisi V;Gandolfi G;Ragazzi M;Nicoli D;Tamagnini I;Piana S;Ciarrocchi A
粘附分子谱的改变可能会改变肿瘤细胞与周围微环境相互作用的方式。钙粘蛋白家族是一大组跨膜蛋白，其决定细胞相互作用的特异性。上皮-间质转化（EMT）过程中发生的钙粘蛋白转换有助于松弛上皮组织的刚性组织并增强肿瘤细胞的运动性和侵袭性。最近，我们发现钙粘蛋白-6（CDH 6，也称为K-CAD）在甲状腺肿瘤细胞中高度表达，这些甲状腺肿瘤细胞显示间充质特征和侵袭性表型，转录调节因子Id 1过表达。在这项工作中，我们探讨了CDH 6是甲状腺肿瘤EMT计划的一部分的可能性。我们证明CDH 6是一种新的转化生长因子-β（TGF-β）靶点，其表达在体外和甲状腺肿瘤患者中与其他EMT间充质标志物类似。我们首次发现CDH 6在人甲状腺癌中表达，并且其表达在肿瘤的侵袭性前沿增强。最后，我们表明，CDH 6是在转录因子RUNX 2的控制下，我们以前描述为甲状腺肿瘤细胞中Id 1促侵袭功能的关键介质。总体而言，这些观察结果提供了新的信息EMT程序在肿瘤进展的机制，并表明CDH 6作为一个潜在的调节甲状腺肿瘤的侵袭性。
Modifications in adhesion molecules profile may change the way tumor cells interact with the surrounding microenvironment. The Cadherin family is a large group of transmembrane proteins that dictate the specificity of the cellular interactions. The Cadherin switch that takes place during epithelial-mesenchymal transition (EMT) contributes to loosening the rigid organization of epithelial tissues and to enhancing motility and invasiveness of tumor cells. Recently, we found Cadherin-6 (CDH6, also known as K-CAD) highly expressed in thyroid tumor cells that display mesenchymal features and aggressive phenotype, following the overexpression of the transcriptional regulator Id1. In this work, we explored the possibility that CDH6 is part of the EMT program in thyroid tumors. We demonstrate that CDH6 is a new transforming growth factor-β (TGF-β) target and that its expression is modulated similarly to other EMT mesenchymal markers, both in vitro and in thyroid tumor patients. We show for the first time that CDH6 is expressed in human thyroid carcinomas and that its expression is enhanced at the invasive front of the tumor. Finally, we show that CDH6 is under the control of the transcription factor RUNX2, which we previously described as a crucial mediator of the Id1 pro-invasive function in thyroid tumor cells. Overall, these observations provide novel information on the mechanism of the EMT program in tumor progression and indicate CDH6 as a potential regulator of invasiveness in thyroid tumors.
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影响因子：
5.8
作者：
Endo, Toyoshi;Ohta, Kazuyasu;Kobayashi, Tetsuro
通讯作者：
Kobayashi, Tetsuro
TGFβ 信号的背景
DOI：
10.1038/nrm3434
发表时间：
2012-10
期刊：
Nature reviews. Molecular cell biology
影响因子：
--
作者：
通讯作者：
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影响因子：
2.7
作者：
Inoue, T;Chisaka, O;Takeichi, M
通讯作者：
Takeichi, M
影响因子：
6
作者：
Nagaharu, Keiki;Zhang, Xinhui;Imanaka-Yoshida, Kyoko
通讯作者：
Imanaka-Yoshida, Kyoko
影响因子：
3.5
作者：
Inoue, Yukiko U.;Asami, Junko;Inoue, Takayoshi
通讯作者：
Inoue, Takayoshi