The road less traveled: regulation of leukocyte migration across vascular and lymphatic endothelium by galectins.

The road less traveled: regulation of leukocyte migration across vascular and lymphatic endothelium by galectins.
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DOI:
10.1007/s10875-010-9460-z
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发表时间:
2011-02
影响因子:
9.1
通讯作者:
Baum, Linda G.
Baum, Linda G.
中科院分区:
医学2区
文献类型:
--
作者:
Thiemann, Sandra;Baum, Linda G.

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Leukocyte entry from the blood into inflamed tissues, exit into the lymphatics, and migration to regional lymph nodes are all crucial processes for mounting an effective adaptive immune response. Leukocytes must cross two endothelial cell layers, the vascular and the lymphatic endothelial cell layers, during the journey from the blood to the lymph node. The proteins and cellular interactions which regulate leukocyte migration across the vascular endothelium are well studied; however, little is known about the factors that regulate leukocyte migration across the lymphatic endothelium. Here, we will summarize evidence for a role for galectins, a family of carbohydrate-binding proteins, in regulating leukocyte migration across the vascular endothelium and propose that galectins are also involved in leukocyte migration across the lymphatic endothelium.
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