Neurocognitive Performance Improvement after Obstructive Sleep Apnea Treatment: State of the Art.
Neurocognitive Performance Improvement after Obstructive Sleep Apnea Treatment: State of the Art.
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阻塞性睡眠呼吸暂停治疗后神经认知能力的改善：最新技术水平。
DOI：
10.3390/bs11120180
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发表时间：
2021-12-16
期刊：
影响因子：
--
通讯作者：
La Mantia I
中科院分区：
文献类型：
--
作者：
Pollicina I;Maniaci A;Lechien JR;Iannella G;Vicini C;Cammaroto G;Cannavicci A;Magliulo G;Pace A;Cocuzza S;Di Luca M;Stilo G;Di Mauro P;Bianco MR;Murabito P;Bannò V;La Mantia I
背景：阻塞性睡眠呼吸暂停（OSA）综合征是一种呼吸性睡眠障碍，其特征是部分或完全发作的上呼吸道塌陷，并伴有气流减少或完全停止。尽管两者之间的联系仍有争议，但一些机制，如间歇性低氧血症、睡眠剥夺、高碳酸血症对下丘脑-垂体-肾上腺轴的破坏，都与神经认知能力低下有关。治疗OSAS患者的不同治疗方法有：持续气道正压通气（CPAP）、下颌推进装置（MAD）、手术；然而，对神经认知功能的影响仍存在争议。本文通过回顾文献，介绍OSAS治疗对神经认知能力的影响。方法：我们使用以下关键词对过去20年的英语语言进行了全面的回顾：神经认知表现和睡眠呼吸暂停，神经认知改善和CPAP， OSAS和认知功能障碍。我们将OSA治疗与神经认知表现改善相关的分析论文纳入其中。所有用于测量不同神经认知性能改善的有效测试都被考虑在内。结果：70篇论文报道了CPAP治疗后OSA患者神经认知能力的改善。80%的研究发现执行功能得到改善，如语言流畅性或工作记忆，在长期随访中部分神经恢复。一篇文章比较了MAD和CPAP治疗对认知障碍的影响，报告CPAP和MAD在认知功能方面的改善优于安慰剂。结论：CPAP治疗似乎可以改善与OSA相关的认知缺陷。有限的研究评估了其他疗法对认知功能的影响。
Background: Obstructive Sleep Apnea (OSA) syndrome is a respiratory sleep disorder characterized by partial or complete episodes of upper airway collapse with reduction or complete cessation of airflow. Although the connection remains debated, several mechanisms such as intermittent hypoxemia, sleep deprivation, hypercapnia disruption of the hypothalamic–pituitary–adrenal axis have been associated with poor neurocognitive performance. Different treatments have been proposed to treat OSAS patients as continuous positive airway pressure (CPAP), mandibular advancement devices (MAD), surgery; however, the effect on neurocognitive functions is still debated. This article presents the effect of OSAS treatments on neurocognitive performance by reviewing the literature. Methods: We performed a comprehensive review of the English language over the past 20 years using the following keywords: neurocognitive performance and sleep apnea, neurocognitive improvement and CPAP, OSAS, and cognitive dysfunction. We included in the analysis papers that correlated OSA treatment with neurocognitive performance improvement. All validated tests used to measure different neurocognitive performance improvements were considered. Results: Seventy papers reported neurocognitive Performance improvement in OSA patients after CPAP therapy. Eighty percent of studies found improved executive functions such as verbal fluency or working memory, with partial neural recovery at long-term follow-up. One article compared the effect of MAD, CPAP treatment on cognitive disorders, reporting better improvement of CPAP and MAD than placebo in cognitive function. Conclusions: CPAP treatment seems to improve cognitive defects associated with OSA. Limited studies have evaluated the effects of the other therapies on cognitive function.
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DOI：
10.1164/rccm.200311-1571oc
发表时间：
2004-09-15
影响因子：
24.7
作者：
Barnes, M;McEvoy, RD;Pierce, RJ
通讯作者：
Pierce, RJ
影响因子：
3.9
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Taurone S
影响因子：
2.6
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Vicini, Claudio
影响因子：
2.5
作者：
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通讯作者：
Mondini, Sara
DOI：
10.1017/s1355617710000901
发表时间：
2010-11-01
影响因子：
2.6
作者：
Lau, Esther Yuet Ying;Eskes, Gail A.;Spurr, Kathleen F.
通讯作者：
Spurr, Kathleen F.