Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients.
Oxidative Stress and Inflammation Biomarker Expression in Obstructive Sleep Apnea Patients.
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阻塞性睡眠呼吸暂停患者的氧化应激和炎症生物标志物表达
DOI：
10.3390/jcm10020277
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发表时间：
2021-01-13
影响因子：
3.9
通讯作者：
Taurone S
中科院分区：
文献类型：
--
作者：
Maniaci A;Iannella G;Cocuzza S;Vicini C;Magliulo G;Ferlito S;Cammaroto G;Meccariello G;De Vito A;Nicolai A;Pace A;Artico M;Taurone S
阻塞性睡眠呼吸暂停综合征（OSAS）是一种呼吸性睡眠障碍，其特征是夜间反复发作的上呼吸道部分或完全阻塞。这种阻塞通常发生在上呼吸道气流减少（呼吸不足）或完全停止（呼吸暂停）的情况下，伴有持续的胸-腹呼吸运动。在呼吸不足/呼吸暂停事件期间，不良的肺泡通气降低了动脉血中的氧饱和度（SaO 2）和动脉二氧化碳分压（PaCO 2）的逐渐增加。间歇性缺氧的直接后果是氧化失衡，伴随活性氧产生和促炎和抗炎细胞因子生长的炎症级联激活。肿瘤坏死因子、炎性细胞因子（IL 2、IL 4、IL 6）、脂质过氧化和游离DNA在OSAS患者中增加。然而，尽管在文献中已经描述和分析了不同的风险相关标志物，但尚未阐明特定的炎症生物标志物是否与OSAS诊断及其临床演变/合并症更好地相关。我们进行了科学文献综述，讨论目前在OSAS患者中测试的炎症和氧化应激生物标志物及其与疾病严重程度和治疗的相关性。
Obstructive Sleep Apnea Syndrome (OSAS) is a respiratory sleep disorder characterised by repeated episodes of partial or complete obstruction of the upper airway during the night. This obstruction usually occurs with a reduction (hypopnea) or complete cessation (apnea) of the airflow in the upper airways with the persistence of thoracic-diaphragmatic respiratory movements. During the hypopnea/apnea events, poor alveolar ventilation reduces the oxygen saturation in the arterial blood (SaO2) and a gradual increase in the partial arterial pressure of carbon dioxide (PaCO2). The direct consequence of the intermittent hypoxia is an oxidative imbalance, with reactive oxygen species production and the inflammatory cascade’s activation with pro and anti-inflammatory cytokines growth. Tumour necrosis factors, inflammatory cytokines (IL2, IL4, IL6), lipid peroxidation, and cell-free DNA have been found to increase in OSAS patients. However, even though different risk-related markers have been described and analysed in the literature, it has not yet been clarified whether specified inflammatory bio-markers better correlates with OSAS diagnosis and its clinical evolution/comorbidities. We perform a scientific literature review to discuss inflammatory and oxidative stress biomarkers currently tested in OSAS patients and their correlation with the disease’s severity and treatment.
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影响因子：
--
作者：
Ermakov AV;Konkova MS;Kostyuk SV;Izevskaya VL;Baranova A;Veiko NN
通讯作者：
Veiko NN
影响因子：
3.1
作者：
Del Ben M;Fabiani M;Loffredo L;Polimeni L;Carnevale R;Baratta F;Brunori M;Albanese F;Augelletti T;Violi F;Angelico F
通讯作者：
Angelico F
DOI：
10.1590/0001-3765201820170730
发表时间：
2018-12-01
期刊：
Anais da Academia Brasileira de Ciências
影响因子：
--
作者：
BILLER, JAQUELINE D.;TAKAHASHI, LEONARDO S.
通讯作者：
TAKAHASHI, LEONARDO S.
影响因子：
158.5
作者：
Bradley, TD;Logan, AG;Floras, JS
通讯作者：
Floras, JS
影响因子：
0.9
作者：
Bakan, Ebubekir;Fidan, Vural;Cokluk, Erdem
通讯作者：
Cokluk, Erdem