Role of progesterone in nicotine addiction: evidence from initiation to relapse.
Role of progesterone in nicotine addiction: evidence from initiation to relapse.
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DOI：
10.1037/a0021265
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发表时间：
2010-12
影响因子：
2.3
通讯作者：
Sofuoglu M
中科院分区：
文献类型：
--
作者：
Lynch WJ;Sofuoglu M
在发达国家，尼古丁成瘾仍然是可预防死亡的主要原因。与男性和男孩相比，女性和十几岁的女孩在尼古丁成瘾的某些方面似乎更容易受到伤害。虽然尼古丁成瘾的性别差异机制尚不清楚，但有证据表明，雌激素可能是女性更易受伤害的基础，而黄体酮可能保护女性。因此，黄体酮可能对烟草成瘾有治疗作用，特别是对女性吸烟者。更深入地了解黄体酮在尼古丁成瘾中的作用不仅从治疗的角度来看很重要，而且从预防的角度来看也很重要：激素过渡阶段，例如发生在青春期、怀孕期间和出生后的阶段，以及随后的激素控制阶段（例如，使用激素避孕方法），都可能导致尼古丁成瘾易感性的变化。在这篇综述中，我们总结了最近的临床和临床前研究的证据，研究了黄体酮在尼古丁成瘾中的作用，重点是它在开始使用和成瘾过程的后期阶段作为潜在的复发预防治疗的作用。我们总结了未来的方向，包括进一步研究黄体酮作为尼古丁成瘾的潜在干预和治疗。
Nicotine addiction continues to be the main cause of preventable death in developed countries. Women and teen girls appear to be more vulnerable on certain aspects of nicotine addiction compared with men and boys. While the mechanism of gender differences in nicotine addiction is not yet clear, evidence suggests that while estrogen may underlie enhanced vulnerability in females, progesterone may protect females. Thus, progesterone may have therapeutic use for tobacco addiction, especially in female smokers. A greater understanding of the role of progesterone in nicotine addiction is important not only from a treatment standpoint, but also from a prevention standpoint: hormone transition phases, such as those that occur at adolescence, and during pregnancy and following birth, as well as following hormonal manipulation (e.g., using methods of hormonal birth control), may all contribute to changes in vulnerability to nicotine addiction. In this review, we summarize recent evidence from clinical and preclinical studies examining the role of progesterone in nicotine addiction focusing on its role during initiation of use and during later phases of the addiction process as a potential relapse prevention treatment. We conclude with future directions including further examination of progesterone as a potential intervention and treatment of nicotine addiction.
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影响因子：
5.5
作者：
Colman, GJ;Joyce, T
通讯作者：
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影响因子：
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