ANGPTL8: An Important Regulator in Metabolic Disorders.

ANGPTL8: An Important Regulator in Metabolic Disorders.
复制标题

DOI:
10.3389/fendo.2018.00169
复制
发表时间:
2018
影响因子:
5.2
通讯作者:
Peng D
Peng D
中科院分区:
医学2区
文献类型:
--
作者:
Luo M;Peng D

文献摘要

参考文献

被引文献

相似文献

血管生成素样蛋白8(angiopoietin-like protein 8,ANGPTL 8)在β细胞增殖和糖尿病进展中的作用长期存在争议,使其成为研究热点。最近,争议得到了解决。虽然ANGPTL 8不能控制β细胞扩增和胰岛功能,但由于其独特的结构和对脂质代谢的关键作用,ANGPTL 8仍然被认为是ANGPTL家族中的一个新的但非典型的成员。此外,ANGPTL 8还参与了非酒精性脂肪肝和肾功能不全等疾病的发生。了解ANGPTL 8的特征可能为代谢相关疾病提供新的诊断和治疗方法。因此,我们回顾了关于ANGPTL 8的最新研究结果,旨在提供ANGPTL 8的综合图片。
Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. Besides, ANGPTL8 also participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. Therefore, we reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8.
DOI: 10.18632/oncotarget.13061
发表时间: 2016-12-06
期刊: Oncotarget
影响因子: --
作者:
Chen S;Chen J;Meng XL;Shen JS;Huang J;Huang P;Pu Z;McNeill NH;Grayburn PA
通讯作者: Grayburn PA
DOI: 10.1186/s12933-015-0326-9
发表时间: 2016-01-07
影响因子: 9.3
作者:
Chen CC;Susanto H;Chuang WH;Liu TY;Wang CH
通讯作者: Wang CH
人类 2 型糖尿病和肥胖症中循环脂肪酶/β-肌营养蛋白升高。
DOI: 10.1038/srep05013
发表时间: 2014-05-23
期刊: Scientific reports
影响因子: 4.6
作者:
Fu Z;Berhane F;Fite A;Seyoum B;Abou-Samra AB;Zhang R
通讯作者: Zhang R
DOI: 10.1016/j.trsl.2017.03.001
发表时间: 2017-06-01
影响因子: 7.8
作者:
Ejarque, Miriam;Borlaug, Marianne;Vendrell, Joan
通讯作者: Vendrell, Joan
DOI: 10.1007/s00125-013-3071-1
发表时间: 2014-01
期刊: DIABETOLOGIA
影响因子: 8.2
作者:
Espes, Daniel;Lau, Joey;Carlsson, Per-Ola
通讯作者: Carlsson, Per-Ola