Altered release of growth hormone and thyrotropin induced by endotoxin in the rat.

Altered release of growth hormone and thyrotropin induced by endotoxin in the rat.
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内毒素诱导的大鼠生长激素和促甲状腺素释放的改变。

DOI:
10.1152/ajpendo.1982.243.4.e332
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发表时间:
1982
期刊:
The American journal of physiology
影响因子:
--
通讯作者:
Martin,JB
Martin,JB
中科院分区:
--
文献类型:
--
作者:
Kasting,NW;Martin,JB

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连续三天测量自由活动大鼠 6 小时的血浆生长激素 (GH) 和促甲状腺素 (TSH) 水平。第1天和第3天不进行治疗,第2天静脉注射内毒素(150mg/kg)。内毒素引起双相温度反应:最初的低温持续 1 小时,随后注射后 5 至 8 小时出现明显的高温。第 1 天观察到的正常脉动 GH 释放在第 2 天被内毒素治疗消除。然而,在第 3 天,GH 分泌量高于初始对照日。 TSH 释放也受到内毒素的抑制,并在第二天出现反弹释放。抗生长抑素血清在所有动物中逆转了内毒素对 GH 分泌的抑制,并且在一些动物中逆转了内毒素对 TSH 分泌的抑制。这些结果表明内毒素是大鼠下丘脑生长抑素释放的有效刺激物。内毒素深刻改变腺垂体激素的释放。
Plasma growth hormone (GH) and thyrotropin (TSH) levels were measured in freely behaving rats for 6 h on three consecutive days. On the 1st and 3rd days there was no treatment, and on the 2nd day endotoxin (150 mg/kg) was administered intravenously. Endotoxin causes a biphasic temperature response: an initial hypothermia persisting for 1 h, followed by hyperthermia evident from 5 to 8 h after injection. Normal pulsatile GH release observed on the 1st day was abolished on the 2nd day by the endotoxin treatment. On the 3rd day, however, GH secretion was greater than on the initial control day. TSH release was also suppressed by endotoxin and showed a rebound release on the subsequent day. The suppression of GH secretion by endotoxin was reversed in all animals by antisomatostatin serum, and the suppression of TSH secretion by endotoxin was reversed in some animals. These results suggest that endotoxin is a potent stimulus for hypothalamic somatostatin release in the rat. Endotoxin profoundly alters adenohypophyseal hormone release.
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