Comparator and non-comparator mechanisms of change detection in the context of speech--an ERP study.
Comparator and non-comparator mechanisms of change detection in the context of speech--an ERP study.
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DOI：
10.1016/j.neuroimage.2008.09.010
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发表时间：
2009-01-15
期刊：
影响因子：
5.7
通讯作者：
Constable RT
中科院分区：
文献类型：
--
作者：
Laufer I;Negishi M;Constable RT
自动变化检测反映了基于认知记忆的比较机制以及基于不同不应状态的感觉非比较机制。本研究的目的是检验不匹配消极成分（MMN）的比较器机制是否受到异常者词汇状态的不同影响。事件相关电位 (ERP) 数据是在“奇怪”范式中收集的，该范式旨在从参与计数任务的 15 名健康受试者中引出 MMN。利用形貌模式分析和源估计来检查嵌入“奇怪”块中的标准偏差对（“deh-day”；“day-deh”；“teh-tay”）引起的偏差（偏差与标准）、认知（偏差与对照对应物）和不应性（标准与对照对应物）效应。我们的结果表明，当变化显着时，无论词汇状态如何（即 /e:/ 到 /eI/ 过渡），响应都会利用位于楔叶/后扣带回的 MMN 的基于比较器的机制，反映对听觉对象的新颖性的敏感性，出现在 P2 潜伏期范围内，主要涉及地形调制。相反，当新颖性较低时（即 /eI/ 到 /e:/ 过渡），会引发声学变化复合体，其中涉及 P1/N1 范围内的强度调制并涉及颞中回。该结果模式也类似于非比较器机制显示的结果模式。这些发现表明，在语音背景下变化检测的比较器机制在空间和时间上存在不同的大脑活动。
Automatic change detection reflects a cognitive memory-based comparison mechanism as well as a sensorial non-comparator mechanism based on differential states of refractoriness. The purpose of this study was to examine whether the comparator mechanism of the Mismatch negativity component (MMN) is differentially affected by the lexical status of the deviant. Event-related potential (ERP) data was collected during an “oddball” paradigm designed to elicit the MMN from 15 healthy subjects that were involved in a counting task. Topography pattern analysis and source estimation were utilized to examine the deviance (deviants vs. standards), cognitive (deviants vs. control counterparts) and refractoriness (standards vs. control counterparts) effects elicited by standard-deviant pairs (“deh-day”; “day-deh”; “teh-tay”) embedded within “oddball” blocks. Our results showed that when the change was salient regardless of lexical status (i.e., the /e:/ to /eI/ transition) the response tapped the comparator based-mechanism of the MMN which was located in the cuneus/posterior cingulate, reflected sensitivity to the novelty of the auditory object, appeared in the P2 latency range and mainly involved topography modulations. In contrast, when the novelty was low (i.e., the /eI/ to /e:/ transition) an acoustic change complex was elicited which involved strength modulations over the P1/N1 range and implicated the middle temporal gyrus. This result pattern also resembled the one displayed by the non-comparator mechanism. These findings suggest spatially and temporally distinct brain activities of comparator mechanisms of change detection in the context of speech.
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影响因子：
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作者：
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