A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition
A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition
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一种紧凑型荧光传感器，用于低成本、无创监测营养不良情况下的肠道通透性
DOI：
10.1117/12.2649030
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Monfort Sánchez E
中科院分区：
文献类型：
--
作者：
Monfort Sánchez E
营养不良与大约45%的5岁以下儿童死亡有关。此外，在2020年，约有1.49亿儿童因营养不足而导致身体/认知发育受损。 环境性肠病（EE）与营养不良有关，其特征是肠道功能的多方面破坏，包括可导致炎症反应的肠道通透性增加。然而，与EE相关的作用和机制（特别是肠道通透性）尚未得到很好的理解。这部分是因为目前评估肠道渗透性变化的技术，如内窥镜活检、组织病理学和化学测试，如乳果糖：甘露糖测定，要么是高度侵入性的，不可靠的，要么难以对特定的患者群体（如婴儿和有尿潴留问题的患者）进行。因此，迫切需要低成本、无创和可靠的诊断工具来更好地评估肠道通透性。在这里，我们提出了一个紧凑的经皮荧光光谱传感器的肠道通透性的非侵入性评估和报告的第一个体内数据收集的志愿者在营养不良的试验。使用这种技术和装置，在口服摄入荧光溶液后，荧光信号被瞬态检测。初步结果表明，所提出的传感器的潜在用途，在低收入环境中的肠道通透性的临床评估。
Undernutrition is associated with approximately 45% of deaths among children under the age of 5. Furthermore, in 2020, around 149 million children suffered impaired physical/cognitive development due to lack of adequate nutrition. Environmental enteropathy (EE) is associated with undernutrition and is characterized by a multifaceted breakdown in gut function, including an increase in intestinal permeability that can lead to inflammatory responses. However, the role and mechanisms associated with EE (particularly gut permeability) are not well understood. This is partly because current techniques to assess changes in gut permeability, such as endoscopic biopsies, histopathology and chemical tests such as Lactulose:Mannitol assays, are either highly invasive, unreliable or difficult to perform on specific groups of patients (such as infants and patients with urine retention problems). Therefore, low-cost, non-invasive and reliable diagnostic tools are urgently needed for better evaluation of intestinal permeability. Here, we present a compact transcutaneous fluorescence spectroscopy sensor for non-invasive evaluation of gut permeability and report the first in vivo data collected from volunteers in an undernutrition trial. Using this technique and device, fluorescence signals are detected transcutaneously after oral ingestion of a fluorescent solution. Preliminary results demonstrate the potential use of the presented sensor for clinical assessment of gut permeability in low-income settings.
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DOI：
10.26355/eurrev_201901_16894
发表时间：
2019-01-01
影响因子：
3.3
作者：
Graziani, C.;Talocco, C.;Scaldaferri, F.
通讯作者：
Scaldaferri, F.
使用口服荧光素和共焦激光内窥镜对赞比亚成年人进行肠道通透性快速检测。
影响因子：
2.2
作者：
Reuben Mbuki;Sandra Chileya;A. Thompson;P. Kelly;V. Kayamba
通讯作者：
V. Kayamba
立场文件：光学活检在环境肠功能障碍研究和诊断中的潜在作用
DOI：
--
发表时间：
2017
期刊：
Nature reviews: Gastroenterology & hepatology
影响因子：
--
作者：
A. Thompson;M. Hughes;S. Anastasova;L. Conklin;Tudor Thomas;C. Leggett;W. Faubion;Thomas J Miller;P. Delaney;F. Lacombe;S. Loiseau;A. Meining;R. Richards;G. Tearney;P. Kelly;Guang
通讯作者：
Guang
使用经皮荧光光谱法快速、无创地测量胃排空率。
影响因子：
3.4
作者：
Aaron M. Lett;Apiradee Lim;C. Skinner;James B Maurice;N. Vergis;A. Darzi;R. Goldin;M. Thursz;A. J. Thompson
通讯作者：
A. J. Thompson