Role of TOR signaling in aging and related biological processes in Drosophila melanogaster.
Role of TOR signaling in aging and related biological processes in Drosophila melanogaster.
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DOI：
10.1016/j.exger.2010.11.036
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发表时间：
2011-05
影响因子：
3.9
通讯作者：
Kapahi, Pankaj
中科院分区：
文献类型：
--
作者：
Katewa, Subhash D.;Kapahi, Pankaj
在过去的几十年里，对模式生物的广泛研究表明，衰老受到深刻的遗传影响。保守的营养感应TOR（雷帕霉素靶）途径正在成为从酵母到哺乳动物的各种物种的寿命和健康寿命的关键调节因子。TOR信号通路在决定真核细胞或细胞系统如何协调其生长、发育和衰老以响应其周围环境的不断变化方面起着关键作用。TOR整合了源自生长因子、营养可用性、能量状态和各种生理应激变化的信号。这些输入中的每一个都专门用于感测特定信号，并将其传送到TOR复合体，TOR复合体又将信号中继到下游输出，以适当地响应环境变化。这些输出包括mRNA翻译，自噬，转录，代谢，细胞存活，增殖和生长以及许多其他细胞过程，其中一些影响生物体寿命。在这里，我们回顾了模式生物果蝇在理解TOR信号转导及其调节的可能影响衰老的各种生物学过程中的贡献。果蝇是第一个发现TOR通路对寿命的营养依赖性影响的生物体。我们还讨论了如何营养感应TOR通路似乎是至关重要的介导的长寿效应的饮食限制（DR），一个强大的环境方法的寿命延长营养限制。目前正在深入研究调节TOR下游寿命的分子机制，希望这些机制可能成为改善年龄相关疾病的潜在靶点，并促进人类健康寿命的延长。
Extensive studies in model organisms in the last few decades have revealed that aging is subject to profound genetic influence. The conserved nutrient sensing TOR (Target Of Rapamycin) pathway is emerging as a key regulator of lifespan and healthspan in various species from yeast to mammals. The TOR signaling pathway plays a critical role in determining how an eukaryotic cell or a cellular system co-ordinates its growth, development and aging in response to constant changes in its surrounding environment? TOR integrates signals originating from changes in growth factors, nutrient availability, energy status and various physiological stresses. Each of these inputs is specialized to sense particular signal(s), and conveys it to the TOR complex which in turn relays the signal to downstream outputs to appropriately respond to the environmental changes. These outputs include mRNA translation, autophagy, transcription, metabolism, cell survival, proliferation and growth amongst a number of other cellular processes, some of which influence organismal lifespan. Here we review the contribution of the model organism Drosophila in the understanding of TOR signaling and the various biological processes it modulates that may impact on aging. Drosophila was the first organism where the nutrient dependent effects of the TOR pathway on lifespan were first uncovered. We also discuss how the nutrient-sensing TOR pathway appears to be critically important for mediating the longevity effects of dietary restriction (DR), a potent environmental method of lifespan extension by nutrient limitation. Identifying the molecular mechanisms that modulate lifespan downstream of TOR is being intensely investigated and there is hope that these are likely to serve as a potential targets for amelioration of age–related diseases and enhance healthful lifespan extension in humans.
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影响因子：
2.1
作者：
CHIPPINDALE, AK;LEROI, AM;ROSE, MR
通讯作者：
ROSE, MR
影响因子：
56.9
作者：
Dobrosotskaya, IY;Seegmiller, AC;Rawson, RB
通讯作者：
Rawson, RB
影响因子：
29
作者：
Bjedov I;Toivonen JM;Kerr F;Slack C;Jacobson J;Foley A;Partridge L
通讯作者：
Partridge L
影响因子：
56.9
作者：
Clancy, DJ;Gems, D;Partridge, L
通讯作者：
Partridge, L
影响因子：
9.2
作者：
Copeland, Jeffrey M.;Cho, Jaehyoung;Walker, David W.
通讯作者：
Walker, David W.