Targeted memory reactivation during sleep to strengthen memory for arbitrary pairings
Targeted memory reactivation during sleep to strengthen memory for arbitrary pairings
复制标题
睡眠期间有针对性的记忆重新激活，以加强对任意配对的记忆
DOI：
10.1016/j.neuropsychologia.2018.12.017
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发表时间：
2019
期刊：
影响因子：
2.6
通讯作者：
Paller, Ken A.
中科院分区：
文献类型：
--
作者：
Vargas, Iliana M.;Schechtman, Eitan;Paller, Ken A.
研究睡眠期间记忆巩固的一种有效方法是利用声波刺激来重新激活记忆。在多项研究中，使用与先前学习相关的声音进行定向记忆再激活（TMR）可以改善后来的记忆，比如回忆以前出现过的物体的位置。在目前的实验中，我们研究了相同技术的一种变体是否可以加强对成对物体位置的记忆。每种声音都自然地与每对声音中的一个物体相连，但我们假设TMR可以改善这两种记忆。我们首先要求参与者记住50对物体中的每一对，方法是将两个物体相互联系起来，并将其中一个物体的声音（例如猫叫）联系起来。接下来，物体被呈现在网格上的独特位置。参与者在一个适应性过程中学习这些位置。在午睡期间，其中25种声音被安静地呈现。在午睡前和午睡后分别进行了两次记忆测试，参与者听到了每一对物体的声音，并被要求回忆第二个物体的名字和两个物体的位置。遗忘分数是用午睡前和午睡后空间回忆错误的平均差值来计算的。我们发现，与没有提示的对象相比，有提示的对象在小睡后的遗忘程度更低。此外，每组中的两名成员的遗忘程度是相似的，但仅限于有提示的两组。因此，研究结果证实了声音在睡眠期间重新激活空间记忆的潜力，从而提高了随后的回忆表现，即使是对于与单个声音相关的多个物体，以及参与者必须学习一种新的声音-物体联系。
A powerful way to investigate memory consolidation during sleep utilizes acoustic stimulation to reactivate memories. In multiple studies, Targeted Memory Reactivation (TMR) using sounds associated with prior learning improved later memory, as in recalling locations where objects previously appeared. In the present experiment, we examined whether a variant of the same technique could strengthen memory for the locations of pairs of objects. Each sound was naturally connected to one object from each pair, but we hypothesized that both memories could be improved with TMR. We first asked participants to memorize each of 50 pairs of objects by associating the two objects with each other and with the sound of one of the objects (e.g., cat-meow). Next, objects were presented in unique locations on a grid. Participants learned these locations in an adaptive procedure. During an afternoon nap, 25 of the sounds were quietly presented. In memory tests given twice before and twice after the nap, participants heard the sound for each object pair and were asked to recall the name of the second object and the locations of both objects. Forgetting scores were calculated using the mean difference between pre-nap and post-nap spatial recall errors. We found less forgetting after the nap for cued compared to non-cued objects. Additionally, the extent of forgetting tended to be similar for the two members of each pair, but only for cued pairs. Results thus substantiate the potential for sounds to reactivate spatial memories during sleep and thereby improve subsequent recall performance, even for multiple objects associated with a single sound and when participants must learn a novel sound-object association.
睡眠期间有针对性的记忆重新激活适应性地促进重叠记忆的加强或减弱
影响因子：
5.3
作者：
Javiera P. Oyarzún;J. Morís;David Luque;R. de Diego;L. Fuentemilla
通讯作者：
L. Fuentemilla
影响因子：
2.7
作者：
Lau, H.;Tucker, M. A.;Fishbein, W.
通讯作者：
Fishbein, W.
影响因子：
25
作者：
de lavilleon, Gaetan;Lacroix, Marie Masako;Benchenane, Karim
通讯作者：
Benchenane, Karim