Associations between Brain Structural Alterations, Executive Dysfunction, and General Psychopathology in a Healthy and Cross-Diagnostic Adult Patient Sample.
Associations between Brain Structural Alterations, Executive Dysfunction, and General Psychopathology in a Healthy and Cross-Diagnostic Adult Patient Sample.
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DOI：
10.1016/j.bpsgos.2021.06.002
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
Pizzagalli DA
中科院分区：
文献类型：
--
作者：
Romer AL;Pizzagalli DA
一般精神病理学因子（p因子）捕获不同样本中精神障碍的共享方差，并可能部分反映执行功能障碍。较高的p因子分数与视觉关联皮层（VAC）和小脑-丘脑-丘脑-皮层回路内的结构改变有关，这两者对执行控制都很重要。在这里，我们测试了这些直接关联的可复制性以及执行功能在健康和交叉诊断的成年患者样本中的间接作用。我们进行了假设驱动（即，感兴趣区域）和探索性全脑结构神经影像学分析，使用来自神经精神表型组学协会（CNP）研究的数据，该研究对272名符合精神分裂症、双相情感障碍或注意力缺陷/多动障碍诊断标准的成年人或健康对照受试者进行。使用结构方程模型，我们研究了结构神经改变（在感兴趣的区域和探索性分析确定的区域内）与p和执行功能因素之间的直接和间接关系。较高水平的p因子与执行功能和VAC灰质体积下降相关，重复了先前的研究。相比之下，我们未能复制以前的p因子和小脑-丘脑-丘脑-皮层电路结构之间的负相关关系。VAC灰质体积和p因子通过执行功能之间也出现了显着的间接关系。全脑分析确定了补充运动区/扣带皮层、前辐射冠和胼胝体中与p因子相关的其他结构改变。执行功能障碍可能是大脑结构与一般精神病理学之间关系的一种机制。与p因子相关的VAC结构改变的复制鼓励进一步关注这种大脑结构。
A general psychopathology factor (p factor) captures shared variance across mental disorders in diverse samples and may partly reflect executive dysfunction. Higher p factor scores have been related to structural alterations within the visual association cortex (VAC) and a cerebello-thalamo-cerebro-cortical circuit, both of which are important for executive control. Here, we tested replicability of these direct associations as well as the indirect role of executive functioning in a sample of healthy and cross-diagnostic adult patients. We conducted hypothesis-driven (i.e., region of interest) and exploratory whole-brain structural neuroimaging analyses using data from the Consortium for Neuropsychiatric Phenomics (CNP) study of 272 adults who met diagnostic criteria for schizophrenia, bipolar disorder, or attention-deficit/hyperactivity disorder or were healthy control subjects. Using structural equation modeling, we examined direct and indirect relations between structural neural alterations (within regions of interest and regions identified from exploratory analyses) and p and executive function factors. Higher levels of the p factor were associated with decreased executive functioning and VAC gray matter volume, replicating previous research. In contrast, we failed to replicate previous negative relations between the p factor and cerebello-thalamo-cerebro-cortical circuit structure. A significant indirect relation between VAC gray matter volume and the p factor via executive function also emerged. Whole-brain analyses identified additional structural alterations in supplementary motor area/cingulate cortex, anterior corona radiata, and corpus callosum genu related to the p factor. Executive dysfunction may be one mechanism underlying relations between brain structure and general psychopathology. Replication of VAC structural alterations related to the p factor encourages further focus on this brain structure.
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影响因子：
7.6
作者：
Durham, E. Leighton;Jeong, Hee Jung;Kaczkurkin, Antonia N.
通讯作者：
Kaczkurkin, Antonia N.
影响因子：
5.7
作者：
Diedrichsen, Joern;Balsters, Joshua H.;Ramnani, Narender
通讯作者：
Ramnani, Narender
DOI：
10.1177/2167702614542463
发表时间：
2015-07-01
期刊：
Clinical psychological science : a journal of the Association for Psychological Science
影响因子：
--
作者：
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通讯作者：
Mittal VA
影响因子：
5.7
作者：
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通讯作者：
Sereno, MI
影响因子：
4.6
作者：
Forbes, Miriam K.;Greene, Ashley L.;Krueger, Robert F.
通讯作者：
Krueger, Robert F.