Serum Irisin as a Potential Biomarker for Cognitive Decline in Vascular Dementia.
Serum Irisin as a Potential Biomarker for Cognitive Decline in Vascular Dementia.
复制标题
DOI：
10.3389/fneur.2021.755046
复制
发表时间：
2021
影响因子：
3.4
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Zhang F;Hou G;Hou G;Wang C;Shi B;Zheng Y
背景：鸢尾素是一种新的运动相关肌因子，已被证明与多种疾病有关，包括严重的神经系统疾病。然而，鸢尾素是否参与血管性痴呆（VD）的发病机制尚未见报道。我们的目的是测定 VD 患者的血清鸢尾素水平并研究其与认知功能的关系。方法：研究对象为2018年7月至2020年6月在山东第一医科大学颈肩腰腿痛医院住院的认知功能正常的VD患者和对照组。入院时进行认知功能评估。采用酶联免疫吸附测定（ELISA）测定血清中鸢尾素的浓度。结果：研究期间，187 名受试者（82 名对照者和 105 名 VD 患者）被纳入分析。 VD患者的血清鸢尾素水平显着低于对照组（p<0.001）。 Spearman分析显示，鸢尾素与HLD-C和MoCA呈正相关，与除HCY外的所有临床特征呈负相关。 Logistic回归分析显示，调整所有临床特征后，VD患者血清鸢尾素与MoCA仍具有显着相关性（β=0.304，p=0.029）。根据受试者工作特征（ROC）曲线分析，血清鸢尾素水平对VD的诊断准确度分别为76%和71%。结论：这些数据表明，即使在调整了危险因素后，血清鸢尾素水平的下降也是 VD 患者认知能力下降的一个强有力的生物标志物。进一步的多中心研究需要证实这种联系，这可能为新的治疗选择铺平道路。
Background: Irisin, a new exercise-related myokine, has been shown to be associated with a variety of diseases including serious neurological disorders. However, whether irisin is involved in the pathogenesis of vascular dementia (VD) has not yet been reported. Our aim is to determine the serum irisin level in patients with VD and investigate its relationship with cognitive function. Methods: The subjects of the study were VD patients and controls with normal cognitive function who were hospitalized in the Neck-Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University from July 2018 to June 2020. Upon admission, a cognitive function assessment was performed. Enzyme-linked immunosorbent assay (ELISA) was used to determine the concentration of irisin in serum. Results: During the study period, 187 subjects (82 controls and 105 VD patients) were included in the analysis. The serum irisin level of VD patients was significantly lower than that of the control group (p < 0.001). Spearman analysis showed that irisin was positively correlated with HLD-C and MoCA, and negatively correlated with all clinical characteristics except for HCY. Logistic regression analysis showed that after adjusting for all clinical characteristics, the serum irisin of VD patients still had a significant correlation with MoCA (β = 0.304, p = 0.029). According to receiver operating characteristic (ROC) curve analysis, the diagnostic accuracy for serum irisin levels on VD was 76% with the sensitivity and 71% with specificity respectively. Conclusions: These data indicate that a decrease in serum irisin levels is a powerful biological marker for cognitive decline in patients with VD, even after adjustment for risk factors. Further multi-center studies need to confirm this connection, which may pave the way for new treatment options.
登录
查看更多内容
影响因子：
9.3
作者：
Tu WJ;Qiu HC;Liu Q;Li X;Zhao JZ;Zeng X
通讯作者：
Zeng X
影响因子：
5.6
作者：
Byun K;Lee S
通讯作者：
Lee S
影响因子：
3.7
作者：
Yan B;Shi X;Zhang H;Pan L;Ma Z;Liu S;Liu Y;Li X;Yang S;Li Z
通讯作者：
Li Z
影响因子：
8.1
作者：
Albrecht, Elke;Schering, Lisa;Maak, Steffen
通讯作者：
Maak, Steffen
影响因子：
5.1
作者：
Choi, Yeon-Kyung;Kim, Mi-Kyung;Park, Keun-Gyu
通讯作者：
Park, Keun-Gyu