Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population.
Decreased level of irisin, a skeletal muscle cell-derived myokine, is associated with post-stroke depression in the ischemic stroke population.
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DOI：
10.1186/s12974-018-1177-6
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发表时间：
2018-05-02
影响因子：
9.3
通讯作者：
Zeng X
中科院分区：
文献类型：
--
作者：
Tu WJ;Qiu HC;Liu Q;Li X;Zhao JZ;Zeng X
抑郁症是脑卒中患者常见的情绪障碍。我们的目的是通过对中国首次急性缺血性卒中（AIS）患者进行为期6个月的随访研究，确定血清中鸢尾素水平并探讨其与卒中后抑郁（PSD）的关系。研究对象为2015年1月至2016年12月在三家卒中中心住院的首次AIS患者。在6个月的随访中进行神经学和神经心理学评估。采用酶联免疫吸附试验（ELISA）测定血清鸢尾素浓度。在研究期间，1205名患者被纳入分析。370例（30.7%）为抑郁症。鸢尾素四分位数的抑郁分布在49.8%（第一个四分位数）和9.9%（第四个四分位数）之间。抑郁症患者血清鸢尾素水平低于无抑郁症患者（P < 0.001）。在使用鸢尾素的第一（Q1）四分位数与Q2-4四分位数以及临床变量的多变量模型中，该标记物显示了预测信息，PSD的风险增加了75% （Q1的优势比[OR]为1.75[95%置信区间[CI]， 1.15-2.65]）。此外，与不含鸢尾素的已知危险因素模型相比，含已知危险因素加鸢尾素模型的区分能力更强；曲线下面积（AUC）由0.77增加到0.81 （95% CI, 0.76 ~ 0.86）。这些数据表明，即使经过变量调整，血清中鸢尾素水平的降低仍是发生PSD风险的强有力的生物学标志物。需要进一步的研究来证实这种关联，这可能为提出新的治疗方案开辟道路。chictr - opc - 17013501。追溯注册于2017年9月23日
Depression is a frequent mood disorder in stroke patient. Our aim was to determine irisin levels in serum and investigate their associations with post-stroke depression (PSD) in a 6-month follow-up study in Chinese patients with first-ever acute ischemic stroke (AIS). The subjects were first-ever AIS patients who were hospitalized at three stroke centers during the period from January 2015 to December 2016. Neurological and neuropsychological evaluations were conducted at the 6-month follow-up. Serum irisin concentrations were measured by enzyme-linked immunosorbent assay (ELISA). During the study period, 1205 patients were included in the analysis. There were 370 patients (30.7%) classified as depression. The depression distribution across the irisin quartiles ranged between 49.8% (first quartile) and 9.9% (fourth quartile). In the patients with depression, serum irisin levels were lower compared with those in patients without depression (P < 0.001). In a multivariate model using the first (Q1) quartile of irisin vs. Q2–4 together with the clinical variables, the marker displayed predictive information and increased risk of PSD by 75% (odds ratio [OR] for Q1, 1.75 [95% confidence interval [CI], 1.15–2.65]). In addition, a model containing known risk factors plus irisin compared with a model containing known risk factors without irisin showed a greater discriminatory ability; the area under the curve (AUC) increased from 0.77 to 0.81 (95% CI, 0.76–0.86). The data suggested that reduced serum levels of irisin were powerful biological markers of risk of developing PSD even after adjustment by variables. Further studies are necessary to confirm this association, which may open the way to the proposal of new therapeutic options. ChiCTR-OPC-17013501. Retrospectively registered 23 September 2017
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影响因子：
9.8
作者：
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通讯作者：
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