Sleep slow oscillations favour local cortical plasticity underlying the consolidation of reinforced procedural learning in human sleep
Sleep slow oscillations favour local cortical plasticity underlying the consolidation of reinforced procedural learning in human sleep
复制标题
睡眠慢振荡有利于局部皮质可塑性，是人类睡眠中强化程序学习的巩固基础
DOI：
10.1111/jsr.13117
复制
发表时间：
2020
影响因子：
4.4
通讯作者：
A. Gemignani
中科院分区：
文献类型：
--
作者：
D. Menicucci;Andrea Piarulli;M. Laurino;A. Zaccaro;Jacopo Agrimi;A. Gemignani
我们研究了在强化学习促进的程序性学习之后的夜间慢波活动和睡眠慢振荡的变化，以及这些变化如何与行为输出相关。在任务会话中，参与者必须达到一个视觉目标，适应光标的移动，以补偿实验引入的角度偏差，而在控制会话中没有应用偏差。在睡前13：00、17：00和23：00以及睡前08：00重复该任务。 偏差角设定为15°（13：00和17：00），并在23：00和08：00时增加至45°（加固）。 对于任务和控制夜晚，进行高密度脑电图睡眠记录（23：30 - 19：30小时）。 与对照组相比，任务组的夜间活动增加：（a）慢波活动（绝对功率）;（B）慢波活动（c）感觉运动区和运动前区的睡眠慢振荡率;（d）运动前区、左感觉运动区和右顶叶区的前下和前上状态的振幅;（e）右顶叶区域的sigma冠状向上状态。任务后的夜晚，我们发现任务性能的改善，显示相关的睡眠慢振荡率在右前运动，感觉运动和顶叶区域。这些发现表明睡眠慢振荡在程序性记忆巩固中的关键作用。睡眠慢振荡的不同组成部分选择性地反映了与程序性视觉任务的强化学习相关的网络激活。事实上，特别涉及任务的区域突出表现为睡眠慢振荡率和夜间任务表现改善之间的显着关联。
We investigated changes of slow‐wave activity and sleep slow oscillations in the night following procedural learning boosted by reinforcement learning, and how these changes correlate with behavioural output. In the Task session, participants had to reach a visual target adapting cursor's movements to compensate an angular deviation introduced experimentally, while in the Control session no deviation was applied. The task was repeated at 13:00 hours, 17:00 hours and 23:00 hours before sleep, and at 08:00 hours after sleep. The deviation angle was set at 15° (13:00 hours and 17:00 hours) and increased to 45° (reinforcement) at 23:00 hours and 08:00 hours. Both for Task and Control nights, high‐density electroencephalogram sleep recordings were carried out (23:30−19:30 hours). The Task night as compared with the Control night showed increases of: (a) slow‐wave activity (absolute power) over the whole scalp; (b) slow‐wave activity (relative power) in left centro‐parietal areas; (c) sleep slow oscillations rate in sensorimotor and premotor areas; (d) amplitude of pre‐down and up states in premotor regions, left sensorimotor and right parietal regions; (e) sigma crowning the up state in right parietal regions. After Task night, we found an improvement of task performance showing correlations with sleep slow oscillations rate in right premotor, sensorimotor and parietal regions. These findings suggest a key role of sleep slow oscillations in procedural memories consolidation. The diverse components of sleep slow oscillations selectively reflect the network activations related to the reinforced learning of a procedural visuomotor task. Indeed, areas specifically involved in the task stand out as those with a significant association between sleep slow oscillations rate and overnight improvement in task performance.
登录
查看更多内容
影响因子：
2.5
作者：
Ghilardi, M. Felice;Moisello, Clara;Krakauer, John W.
通讯作者：
Krakauer, John W.
DOI：
10.1016/0197-2456(88)90049-9
发表时间：
1988-12-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
LACHIN, JM;MATTS, JP;WEI, LJ
通讯作者：
WEI, LJ
影响因子：
5.6
作者：
E. Landsness;D. Crupi;B. Hulse;M. Peterson;R. Huber;R. Huber;H. Ansari;Michael Coen;C. Cirelli;R. Benca;M. Ghilardi;G. Tononi
通讯作者：
E. Landsness;D. Crupi;B. Hulse;M. Peterson;R. Huber;R. Huber;H. Ansari;Michael Coen;C. Cirelli;R. Benca;M. Ghilardi;G. Tononi
影响因子：
5.6
作者：
Riedner, Brady A.;Vyazovskiy, Vladyslav V.;Tononi, Giulio
通讯作者：
Tononi, Giulio