Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage.
Susceptibility tensor imaging and tractography of collagen fibrils in the articular cartilage.
复制标题
关节软骨中胶原蛋白原纤维的敏感性张量成像和拖拉术。
DOI：
10.1002/mrm.26882
复制
发表时间：
2017-11
影响因子：
3.3
通讯作者：
Liu C
中科院分区：
文献类型：
--
作者：
Wei H;Gibbs E;Zhao P;Wang N;Cofer GP;Zhang Y;Johnson GA;Liu C
研究关节软骨内胶原纤维的B0取向相关磁化率，并确定磁化率张量成像(STI)能否检测到软骨内的三维(3D)胶原网络。从9.4特斯拉(T)的固定猪关节软骨标本获得多回波梯度回波数据(100微米各向同性分辨率)。磁化率张量是使用在相对于B0的12或15个不同取向上采集的相位图像来计算的。对胶原纤维的磁化率各向异性进行量化，并将扩散张量成像(DTI)与STI进行比较。用DTI和STI对胶原纤维进行三维显影和追踪。STI实验显示关节软骨内胶原纤维具有明显的各向异性磁化率。STI可用于测量和量化磁化率各向异性图。此外，STI通过3D纤维束成像提供底层胶原网络的方位信息。这项研究的结果表明，在扩散各向异性失效的地方，STI可以表征胶原纤维的取向变化。我们认为STI可以作为一种敏感的、无创的标记物来研究胶原纤维的微结构。
To investigate the B0 orientation-dependent magnetic susceptibility of collagen fibrils within the articular cartilage and to determine whether susceptibility tensor imaging (STI) can detect the three-dimensional (3D) collagen network within cartilage. Multi-echo gradient echo datasets (100-micron isotropic resolution) were acquired from fixed porcine articular cartilage specimens at 9.4 Tesla (T). The susceptibility tensor was calculated using phase images acquired at 12 or 15 different orientations relative to B0. The susceptibility anisotropy of the collagen fibril was quantified and diffusion tensor imaging (DTI) was compared against STI. 3D tractography was performed to visualize and track the collagen fibrils with DTI and STI. STI experiments showed the distinct and significant anisotropic magnetic susceptibility of collagen fibrils within the articular cartilage. STI can be used to measure and quantify susceptibility anisotropy maps. Furthermore, STI provides orientation information of the underlying collagen network via 3D tractography. The findings of this study demonstrate STI can characterize the orientation variation of collagen fibrils where diffusion anisotropy fails. We believe that STI could serve as a sensitive and noninvasive marker to study the collagen fibrils microstructure.
登录
查看更多内容
影响因子：
5.7
作者：
Liu, Chunlei;Li, Wei;Wu, Bing;Jiang, Yi;Johnson, G. Allan
通讯作者：
Johnson, G. Allan
影响因子：
3.3
作者：
Dimov, Alexey V.;Liu, Zhe;Wang, Yi
通讯作者：
Wang, Yi
影响因子：
5.7
作者：
Liu, Chunlei;Li, Wei;Johnson, G. Allan;Wu, Bing
通讯作者：
Wu, Bing
影响因子：
3.3
作者：
Jordan, Caroline D.;Saranathan, Manojkumar;Gold, Garry E.
通讯作者：
Gold, Garry E.
影响因子：
5.7
作者：
Liu, Chunlei;Li, Wei
通讯作者：
Li, Wei