High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility.
High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility.
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DOI：
10.1016/j.neuroimage.2011.02.024
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发表时间：
2011-06-01
期刊：
影响因子：
5.7
通讯作者：
Wu, Bing
中科院分区：
文献类型：
--
作者：
Liu, Chunlei;Li, Wei;Johnson, G. Allan;Wu, Bing
包裹在神经轴突周围的多层髓鞘对于中枢神经系统的正常运作是必不可少的。髓鞘形成异常会导致多种神经系统疾病和发育障碍。髓鞘含量的无创性成像具有重要的临床意义。目前的工作表明，颤抖小鼠中枢神经系统中髓鞘的丢失会导致白质轴突磁化率的显著降低。这种减少导致灰质和白质之间的易感性对比几乎消失。对9.4T的对照组和寒战组小鼠进行了定量磁化率成像和扩散张量成像，测量了每只小鼠全脑的共振频率分布。计算磁化率图并比较两组间的差异。结果表明，颤抖组的灰质和白质之间的磁化率对比度比对照组降低了96%。扩散测量进一步证实了颤抖小鼠的完整纤维通路，排除了轴突损伤及其对易感性改变的潜在贡献。寒战是一种常染色体隐性突变，其特征是几乎完全缺乏中枢神经系统髓鞘。我们的数据提供了新的证据，表明髓鞘是磁共振成像中观察到的深灰质和白质易感性差异的主要来源。更重要的是，目前的研究表明，定量磁化率是髓鞘形成的潜在内源性生物标志物。
The multilayered myelin sheath wrapping around nerve axons is essential for proper functioning of the central nervous system. Abnormal myelination leads to a wide range of neurological diseases and developmental disorders. Non-invasive imaging of myelin content is of great clinical importance. The present work demonstrated that loss of myelin in the central nervous system of the shiverer mouse results in a dramatic reduction of magnetic susceptibility in white matter axons. The reduction resulted in a near extinction of susceptibility contrast between gray and white matter. Quantitative magnetic susceptibility imaging and diffusion tensor imaging were conducted on a group of control and shiverer mice at 9.4 T. We measured the resonance frequency distribution of the whole brain for each mouse. Magnetic susceptibility maps were computed and compared between the two groups. It was shown that the susceptibility contrast between gray and white matter was reduced by 96% in the shiverer compared to the controls. Diffusion measurements further confirmed intact fiber pathways in the shiverer mice, ruling out the possibility of axonal injury and its potential contribution to the altered susceptibility. As an autosomal recessive mutation, shiverer is characterized by an almost total lack of central nervous system myelin. Our data provides new evidences indicating that myelin is the predominant source of susceptibility differences between deep gray and white matter observed in magnetic resonance imaging. More importantly, the present study suggests that quantitative magnetic susceptibility is a potential endogenous biomarker for myelination.
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DOI：
10.1006/jmrb.1994.1037
发表时间：
1994-03-01
期刊：
JOURNAL OF MAGNETIC RESONANCE SERIES B
影响因子：
--
作者：
BASSER, PJ;MATTIELLO, J;LEBIHAN, D
通讯作者：
LEBIHAN, D
影响因子：
1.7
作者：
Klingberg, T;Vaidya, CJ;Hedehus, M
通讯作者：
Hedehus, M
DOI：
10.1073/pnas.0610821104
发表时间：
2007-07-10
影响因子：
11.1
作者：
Duyn, Jeff H.;van Gelderen, Peter;Fukunaga, Masaki
通讯作者：
Fukunaga, Masaki
影响因子：
5.3
作者：
Harroch, S;Palmeri, M;Schlessinger, J
通讯作者：
Schlessinger, J
影响因子：
4.4
作者：
Haacke, E. Mark;Ayaz, Muhammad;Kirsch, Wolff
通讯作者：
Kirsch, Wolff