Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory.
Frequency matters: how changes in hippocampal theta frequency can influence temporal coding, anxiety-reduction, and memory.
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DOI：
10.3389/fnsys.2022.998116
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发表时间：
2022
影响因子：
3
通讯作者：
Lever, Colin
中科院分区：
文献类型：
--
作者：
Hines, Miranda;Poulter, Steven;Douchamps, Vincent;Pibiri, Francesca;McGregor, Anthony;Lever, Colin
相对于θ功率、相位、相干性和交叉频率耦合，海马θ频率是一个有点被忽视的话题。因此，在这里，我们回顾和提出新的数据变化海马θ频率，专注于功能协会（时间编码，焦虑减少，学习和记忆）。以啮齿动物海马θ频率与奔跑速度的关系为模型，我们确定了两个双重分离的频率分量：（a）θ频率与刺激速率关系的斜率分量（“θ斜率”）;和（B）其y轴截距频率（“θ截距”）。我们确定了海马θ频率的三个紧张性决定因素。(1)温度越高，θ频率越高，这可能与热时被判断为较短的时间间隔一致。最初的证据表明，这是通过“θ斜率”组件发生的。(2)具有广泛不同的突触后和突触前主要靶点的抗焦虑药物具有减少“θ截距”组分的作用，支持涉及海马体的焦虑减少的最终共同途径的概念。(3)新奇可靠地减少，熟悉增加，θ频率，作用于“θ斜率”组件。这后一发现的可靠性，以及学习的新颖性的特殊地位，促使我们提出了一个新奇诱发物θ频率减慢（NEST）假说，涉及以下要素：（1）海马结构中θ频率减慢是对不同类型和模式的新奇性的普遍反应;（2）新事物引起的θ波慢化是一种适应性反应，其作用是适应新奇引起的额外学习需要;（3）θ波周期延长增强了联想性;（4）甚至部分周期的延长也可能提高关联性;（5）旨在增强学习的人工θ刺激应该使用低端θ频率。
Hippocampal theta frequency is a somewhat neglected topic relative to theta power, phase, coherence, and cross-frequency coupling. Accordingly, here we review and present new data on variation in hippocampal theta frequency, focusing on functional associations (temporal coding, anxiety reduction, learning, and memory). Taking the rodent hippocampal theta frequency to running-speed relationship as a model, we identify two doubly-dissociable frequency components: (a) the slope component of the theta frequency-to-stimulus-rate relationship (“theta slope”); and (b) its y-intercept frequency (“theta intercept”). We identify three tonic determinants of hippocampal theta frequency. (1) Hotter temperatures increase theta frequency, potentially consistent with time intervals being judged as shorter when hot. Initial evidence suggests this occurs via the “theta slope” component. (2) Anxiolytic drugs with widely-different post-synaptic and pre-synaptic primary targets share the effect of reducing the “theta intercept” component, supporting notions of a final common pathway in anxiety reduction involving the hippocampus. (3) Novelty reliably decreases, and familiarity increases, theta frequency, acting upon the “theta slope” component. The reliability of this latter finding, and the special status of novelty for learning, prompts us to propose a Novelty Elicits Slowing of Theta frequency (NEST) hypothesis, involving the following elements: (1) Theta frequency slowing in the hippocampal formation is a generalised response to novelty of different types and modalities; (2) Novelty-elicited theta slowing is a hippocampal-formation-wide adaptive response functioning to accommodate the additional need for learning entailed by novelty; (3) Lengthening the theta cycle enhances associativity; (4) Even part-cycle lengthening may boost associativity; and (5) Artificial theta stimulation aimed at enhancing learning should employ low-end theta frequencies.
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影响因子：
2.6
作者：
Easton A;Douchamps V;Eacott M;Lever C
通讯作者：
Lever C
影响因子：
2.6
作者：
Chen J;Dastjerdi M;Foster BL;LaRocque KF;Rauschecker AM;Parvizi J;Wagner AD
通讯作者：
Wagner AD
影响因子：
3.5
作者：
Aschoff, J
通讯作者：
Aschoff, J
影响因子：
25
作者：
Brandon, Mark P.;Bogaard, Andrew R.;Hasselmo, Michael E.
通讯作者：
Hasselmo, Michael E.
影响因子：
56.9
作者：
Drieu, Celine;Todorova, Ralitsa;Zugaro, Michael
通讯作者：
Zugaro, Michael