A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation.
A ketogenic diet can mitigate SARS-CoV-2 induced systemic reprogramming and inflammation.
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生酮饮食可以减轻SARS-COV-2引起的全身重编程和炎症。
DOI：
10.1038/s42003-023-05478-7
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发表时间：
2023-11-03
影响因子：
5.9
通讯作者：
Deb, Arjun
中科院分区：
文献类型：
--
作者：
Palermo, Amelia;Li, Shen;ten Hoeve, Johanna;Chellappa, Akshay;Morris, Alexandra;Dillon, Barbara;Ma, Feiyang;Wang, Yijie;Cao, Edward;Shabane, Byourak;Acin-Perez, Rebeca;Petcherski, Anton;Lusis, A. Jake;Hazen, Stanley;Shirihai, Orian S.;Pellegrini, Matteo;Arumugaswami, Vaithilingaraja;Graeber, Thomas G.;Deb, Arjun
生酮饮食（KD）在许多临床研究和疾病动物模型中显示出调节免疫反应和促进全身抗炎状态的益处。在这里，我们研究了KD对SARS-CoV-2感染后小鼠全身毒性的影响。我们的数据表明，在KD下，SARS-CoV-2减少了体重减轻，总体上提高了动物存活率。沉默的多器官转录重编程和代谢重布线表明，KD启动并减轻了病毒诱导的系统性变化。我们观察到心脏中金属蛋白酶减少，炎症稳态蛋白转录增加，血清促炎细胞因子（即TNF-α， IL-15, IL-22, G-CSF, M-CSF, MCP-1），炎症代谢标志物（即犬尿氨酸/色氨酸比率）和炎性前列腺素降低，表明KD感染动物的全身炎症减少。综上所述，这些数据表明，KD可以改变SARS-CoV-2感染后动物的转录和代谢反应，改善小鼠健康，减少炎症，恢复氨基酸、核苷酸、脂质和能量货币代谢。在生酮饮食下对感染SARS-CoV2的小鼠进行的一项全系统研究表明，这种饮食重新编程了感染后动物的转录和代谢反应，改善了健康状况，减少了炎症，恢复了代谢。
The ketogenic diet (KD) has demonstrated benefits in numerous clinical studies and animal models of disease in modulating the immune response and promoting a systemic anti-inflammatory state. Here we investigate the effects of a KD on systemic toxicity in mice following SARS-CoV-2 infection. Our data indicate that under KD, SARS-CoV-2 reduces weight loss with overall improved animal survival. Muted multi-organ transcriptional reprogramming and metabolism rewiring suggest that a KD initiates and mitigates systemic changes induced by the virus. We observed reduced metalloproteases and increased inflammatory homeostatic protein transcription in the heart, with decreased serum pro-inflammatory cytokines (i.e., TNF-α, IL-15, IL-22, G-CSF, M-CSF, MCP-1), metabolic markers of inflammation (i.e., kynurenine/tryptophane ratio), and inflammatory prostaglandins, indicative of reduced systemic inflammation in animals infected under a KD. Taken together, these data suggest that a KD can alter the transcriptional and metabolic response in animals following SARS-CoV-2 infection with improved mice health, reduced inflammation, and restored amino acid, nucleotide, lipid, and energy currency metabolism. A systems-wide study of mice infected with SARS-CoV2 under ketogenic diet shows that this diet reprograms the transcriptional and metabolic response in animals following infection with improved health, reduced inflammation, and restored metabolism.
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