Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.
Hippocampal functional connectivity is related to self-reported cognitive concerns in breast cancer patients undergoing adjuvant therapy.
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DOI：
10.1016/j.nicl.2018.07.010
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Wang L
中科院分区：
文献类型：
--
作者：
Apple AC;Schroeder MP;Ryals AJ;Wagner LI;Cella D;Shih PA;Reilly J;Penedo FJ;Voss JL;Wang L
近四分之三的幸存者在治疗后经历了数月或数年的癌症相关认知障碍(CRCI)。临床和动物研究都指出，海马区可能是慢性脑梗塞的一个受影响的脑区域，然而，以前没有研究探讨海马区在慢性脑梗塞中的功能连接。我们比较了癌症幸存者和健康对照组的海马区连接性，并测试了功能连接性差异与客观和主观认知指标之间的关系。对炎症标志物的探索性分析也在一小部分参与者中进行。FMRI数据是在一项记忆任务中从16名乳腺癌幸存者和17名对照中获得的。NIH工具箱被用来评估认知表现，神经生活质量被用来测量自我报告的认知担忧。全脑组水平的比较发现，在任务期间，幸存者与对照组的海马区连接性不同。平均连接性是从组之间显著差异的聚类中提取的，并与认知表现和主观报告相关。幸存者在情景记忆测试中表现更差，报告称他们比对照组更担心认知问题。探索性分析发现，癌症幸存者的IL6水平高于对照组。与对照组相比，癌症幸存者表现出更高的海马区与左侧楔叶、左侧舌叶、左侧楔前叶和右侧额叶中回的连通性。在幸存者中，与任务相关的较高的海马区-皮质连接性与较差的主观认知关切措施有关。在四个重要的簇中，楔前叶与海马体的较高连接性与幸存者的认知担忧程度较差显著相关。与对照组相比，在幸存者中观察到的更大的海马区-皮质连接是第一个报道的主观关注的功能磁共振生物标记物，可能代表对癌症及其治疗的代偿反应。这种补偿可以在一定程度上解释幸存者报告的认知障碍的主观感受。癌症幸存者在情景记忆测试中的表现比对照组差，并报告了比对照组更多的认知担忧。癌症幸存者表现出明显更高的海马区-皮质连接性，更高的功能连接性与自我报告的认知功能较差相关
Nearly three out of four survivors experience Cancer-Related Cognitive Impairment (CRCI) for months or years following treatment. Both clinical and animal studies point to the hippocampus as a likely brain region affected in CRCI, however no previous study has investigated the functional connectivity of the hippocampus in CRCI. We compared hippocampal connectivity in cancer survivors and healthy controls and tested the relationship between functional connectivity differences and measures of objective and subjective cognition. Exploratory analysis of inflammatory markers was conducted in a small subset of participants as well. FMRI data were acquired during a memory task from 16 breast cancer survivors and 17 controls. The NIH Toolbox was used to assess cognitive performance and Neuro-QoL was used to measure self-reported cognitive concerns. Whole-brain group-level comparisons identified clusters with different connectivity to the hippocampus in survivors versus controls during task. Average connectivity was extracted from clusters of significant difference between the groups and correlated with cognitive performance and subjective report. Survivors performed worse on a test of episodic memory and reported greater cognitive concern than controls. Exploratory analysis found higher IL6 in cancer survivors compared to controls. Cancer survivors demonstrated higher connectivity of hippocampus with left cuneus, left lingual, left precuneus, and right middle prefrontal gyrus compared with controls. In survivors, higher task-related hippocampal-cortical connectivity was related to worse subjective measures of cognitive concern. Of the four significant clusters, higher connectivity of the precuneus with hippocampus was significantly associated with worse cognitive concern in survivors. The observed greater hippocampal-cortical connectivity in survivors compared to controls is the first reported fMRI biomarker of subjective concern, and may represent a compensatory response to cancer and its treatments. This compensation could explain, in part, the subjective feelings of cognitive impairment that were reported by survivors. Cancer survivors performed worse on a test of episodic memory and reported greater cognitive concern than controls Cancer survivors demonstrated significantly higher hippocampal-cortical connectivity Higher functional connectivity was associated with worse self-reported cognitive functioning in cancer survivors
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影响因子：
9.9
作者：
Cella, D.;Lai, J-S.;Moy, C.
通讯作者：
Moy, C.
影响因子：
45.3
作者：
Ahles, Tim A.;Saykin, Andrew J.;Kaufman, Peter A.
通讯作者：
Kaufman, Peter A.
影响因子：
4.8
作者：
de Ruiter, Michiel B.;Reneman, Liesbeth;Schagen, Sanne B.
通讯作者：
Schagen, Sanne B.
DOI：
10.1073/pnas.1113148109
发表时间：
2012-02-28
影响因子：
11.1
作者：
Baldassarre, Antonello;Lewis, Christopher M.;Corbetta, Maurizio
通讯作者：
Corbetta, Maurizio
DOI：
10.1111/mono.12033
发表时间：
2013-08
影响因子：
9.5
作者：
Bauer PJ;Dikmen SS;Heaton RK;Mungas D;Slotkin J;Beaumont JL
通讯作者：
Beaumont JL